HOME >> BIOLOGY >> NEWS
Ultra deep sequencing identifies HIV drug resistance at early stage

Rare, previously undetectable drug-resistant forms of HIV have been identified by Yale School of Medicine researcher Michael Kozal, M.D., using an innovative genome sequencing technology that quickly detects rare viral mutations.

Kozal, associate professor of medicine at Yale and senior author of the retrospective study that used samples from an earlier clinical trial, presented the findings today at the 16th International HIV Drug Resistance Workshop in Barbados. We found that the fraction of HIV patients that harbored resistance mutations is at least twice as high as previously thought, said Kozal, who also directs the HIV Program at the VA Connecticut Healthcare System. These low frequency resistant viral strains are not detectable by current resistance testing methods used in the clinic.

While HIV treatment has been largely successful, with dramatic increases in survival over the last decade, a significant number of patients develop drug resistance shortly after treatment begins. This study was designed to determine if patients that fail therapy early were initially infected with drug resistant HIV strains.

Kozal and his team examined samples from 258 subjects of the FIRST study, a large multi-center five-year U.S. trial comparing three different approaches to antiretroviral therapy. The study evaluated the long-term clinical and virologic effects of three initial antiretroviral drug regimens for treatment-nave HIV infected persons.

Kozal and colleagues used the Genome Sequencer system and Ultra Deep Sequencing technology, which was developed by 454 Life Sciences, to detect additional low abundant resistant variants and to predict the failure of antiretroviral therapy.

454 Sequencing can instantly generate hundreds of thousands of long clonal sequence reads that accurately enable the sensitive detection of rare mutations, said Michael Egholm, vice president of research and development at 454 Life Sciences,
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
15-Jun-2007


Page: 1 2

Related biology news :

1. June 2007 issue of the Journal of Ultrasound in Medicine focuses on contrast-enhanced ultrasound
2. Ultrathin films deliver DNA as possible gene therapy tool
3. Ultrasound could help couples undergoing IVF
4. Ultrasound affects embryonic mouse brain development
5. Ultrasounds show mothers drinking shrinks fetal brain
6. Ultrasound and algae team up to clean mercury from sediments
7. Scientists discover reason behind ear canal in Chinese frog: Ultrasonic communication
8. Ultraviolet B light exposure associated with increased risk of skin cancer
9. Ultrasound a diagnostic tool for space, sports and more
10. Ultralight plane migrating with monarch butterflies to land in Washington
11. Ultra-fast camera captures how hummingbirds hover

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: