HOME >> BIOLOGY >> NEWS
Ultraviolet B light exposure associated with increased risk of skin cancer

A decreased ability to repair chromosomal damage caused by exposure to ultraviolet B (UV-B) radiation in test tubes may be associated with an increased risk of the common skin cancers basal cell carcinoma and squamous cell carcinoma, but not of melanoma, according to a study in the December 21 issue of the Journal of the National Cancer Institute.

Exposure to UV radiation from sunlight is a risk factor for the two most common skin cancers, basal cell carcinoma and squamous cell carcinoma, and for the less common and potentially lethal skin cancer cutaneous malignant melanoma. UV-B radiation can cause strands of DNA to break in sun-exposed skin or skin cells. People with a condition called xeroderma pigmentosum are at a very high risk of sunlight-induced skin cancer because their cells are unable to repair these kinds of DNA and chromosomal damage. However, scientists did not know if the frequency of UV-B induced chromatid breaks, an indirect estimate of DNA repair capacity, is a risk factor for skin cancer in the general population.

Li-E Wang, M.D., and Qingyi Wei, M.D., Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues set out to answer this question by studying 469 patients with both melanoma or nonmelanoma skin cancers and 329 cancer-free patients. They took blood samples from all of the patients and then measured the number of chromatid breaks in the patients' cells 24 hours after the blood samples were exposed to UV-B radiation.

They found that a high number of chromatid breaks was associated with a nearly threefold increased risk of basal cell and squamous cell carcinomas but was not associated with risk of melanoma. The risk of the nonmelanoma skin cancers associated with chromatid breaks increased with increased experimental exposure to UV-B radiation. They also found that sensitivity to UV-B radiation may interact with other known risk factors, such as hair color, skin color, sunbur
'"/>

Contact: Ariel Whitworth
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
20-Dec-2005


Page: 1 2

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Research team enlightens the reasons for severe blindness
3. Coelacanth fossil sheds light on fin-to-limb evolution
4. Molecule blocks gene, sheds light on liver cancer
5. ESA mission highlighted at remote sensing conference
6. Surprising new species of light-harvesting bacterium discovered in Yellowstone
7. Other highlights in the July 24 JNCI
8. Enzyme discovery sheds light on vitamin D
9. Study sheds light on why humans walk on two legs
10. Other highlights from the July 10 JNCI
11. Internal clock, external light regulate plant growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... August 01, 2019 , ... The GENSPEED platform is a compact, ... It is fully developed with over 100 units deployed in the field for multiple ... use, our collaboration with axiVEND will give us a foothold in the USA to ...
(Date:8/1/2019)... ... 2019 , ... USDM Life Sciences (USDM) announces that Jay Crowley, Vice President ... addressing challenges with the upcoming EU MDR IVDR regulations . , ... variety of positions over his 26 years at the FDA, including developing the framework ...
(Date:7/23/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell company, has ... own adipose-derived stem cells to treat their osteoarthritis. The first clinical trial, expected to ... , This is the first of several planned clinical trials which will ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... (PRWEB) , ... August 06, 2019 , ... ... tools for characterizing microbiome populations down to the strain level, has announced partnerships ... kits and other products to companies and research organizations in Australia, Benelux, Indonesia, ...
(Date:7/26/2019)... , ... July 25, 2019 , ... ... leaders through off-the-record collaboration and dialogue, today announces its Boston BD ... Hotel. As part of Biotech Week Boston , the event provides an ...
(Date:7/17/2019)... N.J. (PRWEB) , ... July ... ... announced a long-term strategic agreement for the development and manufacturing of Zolgensma® ... , Through this collaboration, AveXis, a Novartis company, will have dedicated manufacturing ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured ... focuses on regenerative veterinary medicine as a means of improving the quality of life ... the Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it ...
Breaking Biology Technology:
Cached News: