HOME >> BIOLOGY >> NEWS
Unconventional brain circuits offer clues to insomnia-obesity connection

brain cells' roles in arousal and appetite remains largely unexplored, Horvath said.

In a series of experiments in brain slices and in mice, the researchers examined the organization and stability of inputs to hypocretin cell bodies, which act as filters in other brain cells. They found that hypocretin neurons have an "unorthodox" organization in which excitatory currents exert control on nerve cell bodies with minimal inhibitory inputs to filter them.

Overnight food deprivation promoted the formation of more excitatory inputs. Those new inputs were reversed upon refeeding, they reported, an indication of the extreme plasticity of the hypocretin system to prevailing conditions.

That sensitivity and adaptability makes sense, given the neurons' role as the body's natural alarm, rousing one from slumber in response to external cues, Horvath said. However, the structure of the system might also explain the prevalence of sleep disorders and, perhaps, the associated rise in obesity.

"In an evolutionary sense, the response of the hypocretin system to small stimuli would have been necessary for survival," he said. "But in today's chronically stressful environment, the circuitry may also be an underlying cause of insomnia and associated metabolic disturbances, including obesity."


'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
12-Apr-2005


Page: 1 2

Related biology news :

1. Invasion of the brain tumors
2. Preclinical study links gene to brain aneurysm formation
3. Gene variant is associated with brain anatomy, clinical course of ADHD
4. Human knowledge is based upon directed connectivity between brain areas
5. A sensory organ, not the brain, differentiates male and female behavior in some mammals
6. Reading ability protects brain from lead exposure
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Females more prone to brain damage from alcohol abuse
9. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
10. Drug protects brain cells in Huntingtons disease model, researchers find
11. Steroids, not songs, spur growth of brain regions in sparrows

Post Your Comments:
(Date:10/14/2014)... study published in Cancer Research shows SIRT6—a ... colon cancers—can promote the development of skin cancers by ... survival of sun-damaged skin cells. , Previously considered protective, ... called sirtuins that help regulate genomic stability and prevent ... helps repair DNA damage, which can lead to cancer. ...
(Date:10/14/2014)... leading questions is how to produce enough food to ... Food and Agriculture Organization of the United Nations predicts ... 40 years to feed a growing global population, and ... in food production. Plants—grains, cereals, fruits, vegetables, and ... Current research must tap into our knowledge of how ...
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
(Date:10/22/2014)... (PRWEB) October 21, 2014 The ... the inorganic refrigerants market in Americas with analysis ... TOC of the Americas Inorganic Refrigerants Market report, ... provided. This also provides a glimpse of the ... is supported by various tables and figures. ...
(Date:10/22/2014)... San Diego, CA (PRWEB) October 22, 2014 ... laboratory balances from Sartorius, A & D Weighing, ... Sartorius CPA Semi-Micro Balance . The Sartorius ... looking for an affordable high-quality, precise, and user-friendly ... in manufacturing of laboratory equipment, their laboratory balances ...
(Date:10/22/2014)... 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for its Oral Amphotericin B program.  The company ... vitro work involving samples from HIV/AIDS patients ... complete pre clinical studies and regulatory filings to ... trial, utilizing approximately $700,000 of funding and technological ...
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
Cached News: