HOME >> BIOLOGY >> NEWS
Unconventional brain circuits offer clues to insomnia-obesity connection

brain cells' roles in arousal and appetite remains largely unexplored, Horvath said.

In a series of experiments in brain slices and in mice, the researchers examined the organization and stability of inputs to hypocretin cell bodies, which act as filters in other brain cells. They found that hypocretin neurons have an "unorthodox" organization in which excitatory currents exert control on nerve cell bodies with minimal inhibitory inputs to filter them.

Overnight food deprivation promoted the formation of more excitatory inputs. Those new inputs were reversed upon refeeding, they reported, an indication of the extreme plasticity of the hypocretin system to prevailing conditions.

That sensitivity and adaptability makes sense, given the neurons' role as the body's natural alarm, rousing one from slumber in response to external cues, Horvath said. However, the structure of the system might also explain the prevalence of sleep disorders and, perhaps, the associated rise in obesity.

"In an evolutionary sense, the response of the hypocretin system to small stimuli would have been necessary for survival," he said. "But in today's chronically stressful environment, the circuitry may also be an underlying cause of insomnia and associated metabolic disturbances, including obesity."


'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
12-Apr-2005


Page: 1 2

Related biology news :

1. Invasion of the brain tumors
2. Preclinical study links gene to brain aneurysm formation
3. Gene variant is associated with brain anatomy, clinical course of ADHD
4. Human knowledge is based upon directed connectivity between brain areas
5. A sensory organ, not the brain, differentiates male and female behavior in some mammals
6. Reading ability protects brain from lead exposure
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Females more prone to brain damage from alcohol abuse
9. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
10. Drug protects brain cells in Huntingtons disease model, researchers find
11. Steroids, not songs, spur growth of brain regions in sparrows

Post Your Comments:
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
(Date:10/16/2014)... human body. Battles are won, lost or sometimes ... stalemate—known as tumor dormancy—can last up to 25 ... is poorly understood. , A new computational ... a Professor of Chemistry at Princeton University, may ... the switch to a malignant state. Published today ...
(Date:10/16/2014)... Oregon and Washington land managers have a new synthesis ... eastside moist mixed-conifer (MMC) forests in the two states. ... Forests in Eastern Oregon and Washington: A Synthesis of ... Management, a general technical report published by the U.S. ... response to a request from managers for a synthesis ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific Speech ... market in Asia-Pacific with analysis and forecast of revenue. ... in 2014 to $208 million by 2019, at a ... to 2019. , Browse through the TOC of the ... of the in-depth analysis provided. It also provides a ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and ... forecast of revenue. The arthroscopic devices market in Asia ... at a CAGR of 6.5% from 2013 to 2018. ... devices market, to get an idea of the in-depth ... segmentation of arthroscopic devices market in the same region, ...
Breaking Biology Technology:The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: