HOME >> BIOLOGY >> NEWS
Uncovering the molecular basis of obesity

Why does the same diet make some of us gain more weight than others? The answer could be a molecule called Bsx, as scientists from the European Molecular Biology Laboratory (EMBL), the German Institute for Nutrition (DIFE), Potsdam, and the University of Cincinnati report in the current issue of Cell Metabolism. Bsx is the molecular link between spontaneous physical activity and food intake. Mice lacking the molecule show less spontaneous physical activity, perceive hunger signals differently and have a lower concentration of feeding hormones in their brain than normal mice. Being conserved across species Bsx might be a promising target for controlling diet-induced obesity in humans.

Spontaneous physical activity, subconscious movements we make such as fidgeting while working at the computer, and food intake are two crucial factors regulating our body weight. Both are controlled by the same part of the brain, called hypothalamus, and they are intrinsically linked. When we are hungry our spontaneous activity increases and provides us with the drive to go out and find food. Mathias Treier and his group at EMBL have now discovered the molecule that brings about this link between locomotor activity and food intake in mice.

The molecule is called Bsx and is required for spontaneous activity, Treier says. Mice that lack Bsx in their hypothalamus are a lot lazier than normal mice. They show less spontaneous activity and less food seeking behaviour, which is based on locomotor activity.

Bsx brings about its effect by regulating the expression of NPY and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking for food even if they have been starving for an extended period. The scientists suggest Bsx is also needed to enable brain cells to sense and respond to specific hunger signals from the body without it the mice do not feel hunger.

Bsx is
'"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
5-Jun-2007


Page: 1 2

Related biology news :

1. Uncovering the secrets of the deep
2. Uncovering DNAs sweet secret
3. Uncovering sex-change secrets of black sea bass
4. Uncovering how bone marrow stromal cells can potentially regenerate brain tissue
5. New textbook illuminates the close links between evolutionary and molecular biology
6. New molecular regulators of hyperthyroidism and goiter
7. A novel molecular dictator with a conscience discovered
8. UC Santa Barbara scientists clarify molecular basis of interferon action
9. MU researchers make discovery in molecular mechanics of phototropism
10. Malaria-resistant mosquitoes battle disease with molecular warhead
11. University of Cincinnati receives $1.7M to research molecular treatment of brain injury

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Uncovering the molecular basis obesity

(Date:7/27/2014)... might have survived the asteroid strike that wiped them ... later in history, scientists say. , A fresh study ... helped palaeontologists to build a new narrative of the ... They found that in the few million years before ... was experiencing environmental upheaval. This included extensive volcanic activity, ...
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
(Date:7/25/2014)... the first broad-scale estimate of air pollution removal by ... that trees are saving more than 850 human lives ... symptoms. , While trees, pollution removal equated to an ... the impacts of that improvement are substantial. Researchers valued ... at nearly $7 billion every year in a study ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3First national study finds trees saving lives, reducing respiratory problems 2
(Date:7/28/2014)... new method of building materials using light, developed by ... enable technologies that are often considered the realm of ... , Although cloaked starships won,t be a reality ... developed for constructing materials with building blocks a few ... control the way that light flies through them, and ...
(Date:7/28/2014)... July 28, 2014 “2014 ... Lubricant Industry” is a professional and in-depth ... market. The report introduces Lubricant basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
(Date:7/28/2014)... -- Research and Markets has announced the ... report to their offering. ... covers the designing and engineering of completely new biological ... of natural biological systems that provide improved and desirable ... extreme genetic engineering because it not only alters existing ...
(Date:7/28/2014)...  David Hardison, Ph.D., vice president of health ... been elected chairman of the board for the ... to establish common protocols around the use of ... electronic health records. Hardison will ... organizations across the research and health care arena ...
Breaking Biology Technology:Building 'invisible' materials with light 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Global Synthetic Biology Market 2014-2018 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3
Cached News: