HOME >> BIOLOGY >> NEWS
Uncovering the molecular basis of obesity

Why does the same diet make some of us gain more weight than others? The answer could be a molecule called Bsx, as scientists from the European Molecular Biology Laboratory (EMBL), the German Institute for Nutrition (DIFE), Potsdam, and the University of Cincinnati report in the current issue of Cell Metabolism. Bsx is the molecular link between spontaneous physical activity and food intake. Mice lacking the molecule show less spontaneous physical activity, perceive hunger signals differently and have a lower concentration of feeding hormones in their brain than normal mice. Being conserved across species Bsx might be a promising target for controlling diet-induced obesity in humans.

Spontaneous physical activity, subconscious movements we make such as fidgeting while working at the computer, and food intake are two crucial factors regulating our body weight. Both are controlled by the same part of the brain, called hypothalamus, and they are intrinsically linked. When we are hungry our spontaneous activity increases and provides us with the drive to go out and find food. Mathias Treier and his group at EMBL have now discovered the molecule that brings about this link between locomotor activity and food intake in mice.

The molecule is called Bsx and is required for spontaneous activity, Treier says. Mice that lack Bsx in their hypothalamus are a lot lazier than normal mice. They show less spontaneous activity and less food seeking behaviour, which is based on locomotor activity.

Bsx brings about its effect by regulating the expression of NPY and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking for food even if they have been starving for an extended period. The scientists suggest Bsx is also needed to enable brain cells to sense and respond to specific hunger signals from the body without it the mice do not feel hunger.

Bsx is
'"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
5-Jun-2007


Page: 1 2

Related biology news :

1. Uncovering the secrets of the deep
2. Uncovering DNAs sweet secret
3. Uncovering sex-change secrets of black sea bass
4. Uncovering how bone marrow stromal cells can potentially regenerate brain tissue
5. New textbook illuminates the close links between evolutionary and molecular biology
6. New molecular regulators of hyperthyroidism and goiter
7. A novel molecular dictator with a conscience discovered
8. UC Santa Barbara scientists clarify molecular basis of interferon action
9. MU researchers make discovery in molecular mechanics of phototropism
10. Malaria-resistant mosquitoes battle disease with molecular warhead
11. University of Cincinnati receives $1.7M to research molecular treatment of brain injury

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Uncovering the molecular basis obesity

(Date:3/11/2015)... 2015   The Sync Project™ today ... measure and harness music to improve health. The ... objective measurements of physiology, enabling the study of ... large populations. It is designed for medical and ... rigorous studies and accelerate the discovery of the ...
(Date:3/10/2015)... Transforming How We Look at ... in Human Space Flight" by Michael A. ... Ph.D. was recently featured by Springer Science Media, highlighting the ... Specifically, "Personalized Medicine in Human Space Flight" was ... 2013 and 2014 from Springer in the journal ...
(Date:3/10/2015)... Conn. , March 10, 2015  NXT-ID, ... ("NXT-ID" or the "Company"), a biometric authentication company ... the company,s Wocket™ smart wallet has been named ... by Rethink Modern. Rethink Modern ( ... and innovative items for your home and lifestyle that have ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
(Date:3/27/2015)... NEW YORK , 27. März 2015 ... Vilcek Prize in Biomedical Science für seine ... wie Proteine zwischen Zellkompartimenten transportiert werden, sowie ... den Zellen zur Reaktion auf Stress nutzen, ... zusammenhängt. Dr. Walter ist Professor für Biochemie ...
(Date:3/27/2015)... , March 27, 2015 WuXi ... leading open-access R&D capability and technology platform company ... industries, announced today that an Investigational New Drug ... antibody for rheumatoid arthritis has been accepted for ... (CFDA).  In September 2012, MedImmune, ...
(Date:3/26/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... with certain matters, including the appointment of auditors, its ... 26, 2015 (the "Meeting") was adjourned, as previously disclosed ... 11:00 a.m. ( Toronto time). The ... that previous disclosed. The Meeting will reconvene at the ...
(Date:3/26/2015)... March 26, 2015 PAREXEL International ... clinical research organization , announced today ... agreement to acquire all of the business ... leading provider of specialized pharmacovigilance services, based ... collection, detection, assessment, monitoring, and prevention of ...
Breaking Biology Technology:Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
Cached News: