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Under magnetic force, nanoparticles may deliver gene therapy

After binding DNA segments to tiny iron-containing spheres called nanoparticles, researchers have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect. Although the research, done in cell cultures, is in early stages, it may represent a new method for delivering gene therapy to benefit blood vessels damaged by arterial disease.

The nanoparticles are extremely small, ranging from 185 to 375 nanometers (a nanometer is one billionth of a meter, or a millionth of a millimeter). For comparison, red blood cells are ten to 100 times larger. The researchers were able to control the nanoparticle size by varying the amount or composition of solvents they used to form the nanoparticles.

The magnetically driven delivery system also may find broader use as a vehicle for delivering drugs, genes or cells to a target organ. This is a novel delivery system, the first to use a biodegradable, magnetically driven polymer to achieve clinically relevant effects, said study leader Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Childrens Hospital of Philadelphia. This system has the potential to be a powerful tool.

The proof-of-principle study, performed on vascular cells in culture, appears in the August issue of the FASEB Journal, published by the Federation of American Societies for Experimental Biology.

Impregnated with iron oxide, the nanoparticles carry a surface coating of DNA bound to an organic compound called polyethylenimine (PEI). The PEI protected the DNA from being broken down by enzymes called endonucleases that were present in the cell cultures and which occur normally in the bloodstream.

The DNA was in the form of a plasmid, a circular molecule that here carried a gene that coded for a growth-inhibiting protein called adiponectin. By applying a magnetic field, the study team steered the particles into arterial smooth
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Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
31-Jul-2007


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