HOME >> BIOLOGY >> NEWS
Understanding the life of C. elegans

HOUSTON (April 4, 2006) When the nematode Caenorhabditis elegans has enough to eat, enjoys the right temperatures and is not crowded out by its fellows, it produces a hormone, which binds to a receptor called DAF12 that allows it to reach reproductive maturity and live a natural lifespan.

When conditions are harsher, however, the worm a classic model organism frequently studied in the laboratory does not produce the hormone and enters a special stage called the dauer diapause in which it remains an immature larva until the situation improves. In a paper that appears in the journal Developmental Cell, Baylor College of Medicine researchers led by Dr. Adam Antebi, assistant professor in the BCM Huffington Center on Aging and the department of molecular and cellular biology, identify a new gene called DAF-36 involved in making this hormone.

"Our evidence suggests that DAF-36 works early in a pathway that converts cholesterol through a series of enzymatic steps into the dafachronic acids, the active ligands for DAF-12 nuclear receptor," said Antebi. In this instance, a ligand is a molecule that binds to a specific site on a protein.

These particular ligands promote the maturation of the C. elegans reproductive capacity and prevent the organism from going into the immature long-lived larval phase called dauer diapause. Antebi and collaborators identified these ligands in a report that appeared March 24, 2006 in the journal Cell.

In addition, said Antebi, DAF-36 is required for the long life seen in forms of C. elegans that lack germline cells those cells like sperm and egg in animals are necessary for reproduction.

In a related work published in Cell (Motola et al. 2006), the chemical identification of the DAF-12 ligands as steroid-like hormones is reported, providing the first evidence for steroid control of maturation in worms. Antebi speculates that this may resemble how estrogen and androgen hormones similarly gover
'"/>

Contact: Kimberlee Barbour
kbarbour@bcm.edu
713-798-4712
Baylor College of Medicine
4-Apr-2006


Page: 1 2

Related biology news :

1. Understanding why C. difficile causes disease -- its hungry
2. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
3. Understanding occupational safety and health issues of nanotechnology
4. Understanding the Arctic -- NSF-funded expeditions cover new ground in climate science
5. Understanding climate change: Public forum in Philadelphia next week
6. Understanding food nutrition labels challenging for many people
7. Understanding of cell protection mechanism points to therapies to prevent heart attacks and strokes
8. Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
9. Jane Lubchenco receives the 2005 AAAS Public Understanding of Science and Technology Award
10. Understanding the oceans microbes is key to the Earths future
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... MA (PRWEB) , ... June 28, 2017 , ... ... educating and assisting small businesses in their marketing efforts, announced that their new ... accessible in its design, but key on the site is the offering of ...
(Date:6/28/2017)... ... June 28, 2017 , ... Alevio, LLC ... announce the 500th case using the SiCure Sacroiliac Joint Fusion System. , SiCure ... SiCure can be implanted in either a lateral or posterior approach, and ...
(Date:6/28/2017)... ... June 28, 2017 , ... Supplies of the critical medical ... gathered at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2017 annual meeting ... which is used in 30 to 40 million nuclear medicine procedures worldwide every year. ...
(Date:6/27/2017)... ... June 27, 2017 , ... Biodex Medical Systems, Inc. ... aid in one device. This assistive aid lifts patients safely from a seated to ... motorized lift mechanics. The Mobility Assist is the latest in a line of Biodex ...
Breaking Biology Technology:
Cached News: