HOME >> BIOLOGY >> NEWS
Understanding the life of C. elegans

HOUSTON (April 4, 2006) When the nematode Caenorhabditis elegans has enough to eat, enjoys the right temperatures and is not crowded out by its fellows, it produces a hormone, which binds to a receptor called DAF12 that allows it to reach reproductive maturity and live a natural lifespan.

When conditions are harsher, however, the worm a classic model organism frequently studied in the laboratory does not produce the hormone and enters a special stage called the dauer diapause in which it remains an immature larva until the situation improves. In a paper that appears in the journal Developmental Cell, Baylor College of Medicine researchers led by Dr. Adam Antebi, assistant professor in the BCM Huffington Center on Aging and the department of molecular and cellular biology, identify a new gene called DAF-36 involved in making this hormone.

"Our evidence suggests that DAF-36 works early in a pathway that converts cholesterol through a series of enzymatic steps into the dafachronic acids, the active ligands for DAF-12 nuclear receptor," said Antebi. In this instance, a ligand is a molecule that binds to a specific site on a protein.

These particular ligands promote the maturation of the C. elegans reproductive capacity and prevent the organism from going into the immature long-lived larval phase called dauer diapause. Antebi and collaborators identified these ligands in a report that appeared March 24, 2006 in the journal Cell.

In addition, said Antebi, DAF-36 is required for the long life seen in forms of C. elegans that lack germline cells those cells like sperm and egg in animals are necessary for reproduction.

In a related work published in Cell (Motola et al. 2006), the chemical identification of the DAF-12 ligands as steroid-like hormones is reported, providing the first evidence for steroid control of maturation in worms. Antebi speculates that this may resemble how estrogen and androgen hormones similarly gover
'"/>

Contact: Kimberlee Barbour
kbarbour@bcm.edu
713-798-4712
Baylor College of Medicine
4-Apr-2006


Page: 1 2

Related biology news :

1. Understanding why C. difficile causes disease -- its hungry
2. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
3. Understanding occupational safety and health issues of nanotechnology
4. Understanding the Arctic -- NSF-funded expeditions cover new ground in climate science
5. Understanding climate change: Public forum in Philadelphia next week
6. Understanding food nutrition labels challenging for many people
7. Understanding of cell protection mechanism points to therapies to prevent heart attacks and strokes
8. Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
9. Jane Lubchenco receives the 2005 AAAS Public Understanding of Science and Technology Award
10. Understanding the oceans microbes is key to the Earths future
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Understanding the life elegans

(Date:7/23/2014)... Tracking of blue whales by satellite over a 15-year ... whales consistently return to feed in specific locations each ... in the open-access journal PLOS ONE by ... data may be used to mitigate human threats to ... has been slow to recover since the establishment of ...
(Date:7/23/2014)... cultured from cystic fibrosis patients, scientists at the UNC ... have shown that a new CF drug counteracts the ... The finding, published today in the journal Science ... becomes unstable and loses its ability to function properly ... research offers several insights into how novel CF pharmacotherapies ...
(Date:7/23/2014)... , , , , , ... , , , , , ... that changing how medical care is delivered could help prevent multiple chronic diseases and extend healthy lifespan. The idea, they argue, would be to target the... ... , , , , ... , , , , , ...
Breaking Biology News(10 mins):Blue whales' dangerous feeding grounds 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5
(Date:7/23/2014)... /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed drink regimen ... They are the first functional focus beverage to give ... alternative to the temporary fix associated with energy drinks. ... 29, 2014, with hopes to raise $50,000 over the ... http://photos.prnewswire.com/prnh/20140723/129697 Think Drinks were ...
(Date:7/23/2014)... 23 de julio de 2014 ADB ... Compañía) ha anunciado hoy una asociación con Austen ... (ABIA o el Instituto), para el propósito de ... de terapia de señal bioeléctrica (el E-QURE BST ... Instituto, que tiene una importante experiencia en cicatrización ...
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)... 23, 2014 With the ability to record ... for more than 15 minutes, Fastec Imaging has brought the ... high speed imaging. “Finally, a high speed camera that can ... in our everyday lives.” proclaims Matt Kearney, VP of Sales ... been to demystify and simplify the traditionally complicated workflow of ...
Breaking Biology Technology:truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7Fastec Imaging Introduces the First High Speed Camcorder 2Fastec Imaging Introduces the First High Speed Camcorder 3
Cached News: