HOME >> BIOLOGY >> NEWS
Understanding why C. difficile causes disease -- it's hungry

Researchers studying the genetics behind why C. difficile causes disease have come to a simple conclusion -- the bacteria do it because they are starving. That just might help them find a new treatment for what can sometimes be a very difficult disease to treat.

"The genes responsible for toxin production only seem to be expressed during periods of nutrient deprivation. This is consistent with the view that most disease-causing bacteria express their pathogenicity when they are hungry," says Abraham Sonenshein, professor at the Sackler School of Graduate Biomedical Sciences at Tufts University and at Tufts University School of Medicine, at the 107th General Meeting of the American Society for Microbiology (ASM) on May 24, 2007.

C. difficile bacteria are everywhere in soil, air, water, human and animal feces, and on most surfaces in hospital wards. The bacteria don't cause problems until they grow in abnormally large numbers in the intestinal tract. This can happen when the benign bacteria that normally inhabit the intestinal tract are reduced such as when people take antibiotics or other antimicrobial drugs. Then, C. difficile can cause symptoms ranging from diarrhea to life-threatening inflammations of the colon.

In 2002 a new, more virulent strain began appearing in hospitals in the United States and Canada. Recently, this strain was shown to be responsible for more than half of all cases in a representative sampling in Quebec. The highly virulent strain has a much higher toxin production which leads to more destructive and deadly disease, says Vivian Loo of McGill University.

Sonenshein is studying a five-gene region of the bacteriums chromosome known as the tcd locus. Two of the genes code for the toxins the bacterium produces that cause disease and a third gene codes for a protein that makes a hole in the organisms cell envelope to let the toxins out. The last two genes are of greatest interest to Sonenshein a
'"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
24-May-2007


Page: 1 2

Related biology news :

1. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
2. Understanding occupational safety and health issues of nanotechnology
3. Understanding the Arctic -- NSF-funded expeditions cover new ground in climate science
4. Understanding climate change: Public forum in Philadelphia next week
5. Understanding food nutrition labels challenging for many people
6. Understanding of cell protection mechanism points to therapies to prevent heart attacks and strokes
7. Understanding the life of C. elegans
8. Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
9. Jane Lubchenco receives the 2005 AAAS Public Understanding of Science and Technology Award
10. Understanding the oceans microbes is key to the Earths future
11. Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Understanding why difficile causes disease hungry

(Date:11/4/2014)... Nov. 5, 2014 – University of Utah engineers developed ... help jet fuel produce electricity without needing to ignite ... to power portable electronics, off-grid power and sensors. , ... in the American Chemical Society journal ACS Catalysis ... a chemical reaction between a fuel and an oxygen-rich ...
(Date:11/4/2014)... , November 4, 2014   ... vertical market growth   Fuel3D , a ... closed a funding round totaling $6.4 million (£4 million). This ... funding secured earlier this year and paves the way for ... 2015. The funding round was led by Chimera ...
(Date:11/3/2014)... Nov. 3, 2014  NeuroSigma ® , Inc. ... sciences company focused on commercialization of its non-invasive ... the treatment of neurological and neuropsychiatric disorders, announced ... has issued a Notice of Allowance for Mexican ... co-owned by NeuroSigma and the Regents of the ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
(Date:11/26/2014)... On January, 14, 2015, UMBC’s Biotechnology Graduate ... community to the UMBC campus for a discussion on ... Society, will take place from 9 a.m. to 4 ... discussion, presentations and workshops, the free symposium will highlight ... in the industry and the future of protein research. ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 PMG Research, ... Board. PMG Research is a network of sites that provide ... to over 2 million patient lives through its partnerships with ... comprised of 11 hub site locations in the Southeastern United ... first term of the board will be held ...
(Date:11/26/2014)... NC (PRWEB) November 25, 2014 ... Intensity Focused Ultrasound (HIFU) devices, recently participated in ... Small Renal Mass 360° .” Key opinion leaders ... therapeutic advances related to small renal masses while ... about different ablative technologies in hands-on labs. Attendees ...
(Date:11/26/2014)... November 25, 2014 Continuing its award-winning ... earned three prestigious MarCom Awards for outstanding creative achievement ... a Platinum MarCom Award, the organization’s top honor, in ... St. Louis held in April of this year. The ... 14,000 attendees. Additionally, Nerium was awarded a Gold MarCom ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
Cached News: