Unique estrogen receptor linked to metastatic breast cancer

velopment of metastasis.

Results showed that while the two types of receptors, GPR30 and the standard ERs, were commonly found together - their expression was not interdependent. This was best evidenced by the fact that approximately half of the ER-negative tumors remained positive for GPR30.

"This suggests that tumors traditionally viewed as being unreceptive to estrogen, may in fact, remain estrogen responsive," says co-author Edmond Sabo, MD, pathologist at Rhode Island Hospital and assistant professor at Brown Medical School. "If this is the case, it could significantly influence which patients are candidates for hormone therapy."

Researchers also found that GPR30 was positively associated with tumor size, and that primary tumors from patients with metastatic disease were twice as likely to express GPR30.

Alternatively, an inverse relationship was measured between the standard estrogen receptors (ER and ER) and tumor size, and no significant association was found between receptor expression and the presence of metastatic disease.

"Our data indicates that GPR30 promotes tumor growth and is linked to metastatic disease, but also evidences GPR30's autonomy from the standard estrogen receptors," says Filardo. " It strengthens the concept that GPR30 and standard estrogen receptors promote distinct biological responses and invokes a new paradigm regarding our current understanding of breast cancer biology."

Interestingly, although GPR30 was strongly associated with the development of metastatic disease, there was not a connection between the presence of GPR30 and if breast cancer cells had invaded the lymph nodes of a patient.

"Further research is needed to determine if there is a relationship between GPR30 and lymph node invasion," says Filardo. "Given that tumor size and lymph node invasion are well-known predictors of metastases, future studies will focus on determining how cells that test positive for GPR30 spread throughout the

Contact: Megan Martin

Page: 1 2 3

Related biology news :

1. Unique tomatoes tops in disease-fighting antioxidants
2. Unique imaging uncovers the invisible world where surfaces meet
3. Unique gene regulation gives chilly bugs survival advantage at bottom of the world
4. Unique Huntingtons study moves forward
5. Unique dual target specificity of kinase inhibitor key for success against cancer
6. Unique soybean lines hold promise for producing allergy-free soybeans
7. Uniquely human component of language found in gregarious birds
8. Unique equine cataract surgery offered on routine basis
9. Unique interplay between tumor and blood vessel cells promotes angiogenesis and tumor growth
10. Unique genetic profile helps over-45s conceive naturally
11. Unique library of plant genes germinates, takes root at UNC

Post Your Comments:

(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from ... and ProText™, making them the first Wharton’s jelly allografts to be assigned a Q ... company’s solutions are the first Wharton’s jelly allograft product to be recognized as a ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... Phase II contract awarded by the Joint Science & Technology Office—Chemical and Biological ... is to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life ... and compliance, announces a new solution to manage regulated workloads on Microsoft Azure. ... their technology stack complies with FDA and global regulations. USDM's new managed service ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES ... , Bode-CARES provides a turnkey solution that includes a comprehensive collection ...
(Date:7/10/2020)... ... July 09, 2020 , ... In ... commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to ... by Dr MA has been using the zebrafish model to investigate the causes ...
(Date:7/7/2020)... ... 06, 2020 , ... R3 International is now offering stem cell therapy for ... cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or with ... form of Alzheimers dementia, and the incidence continues to increase as individuals live longer. ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift ... 40% in 2020, despite many obstacles created as a result of COVID-19. As ... for its partnered medical practices and medical manufacturers by expanding access to device ...
Breaking Biology Technology:
Cached News: