HOME >> BIOLOGY >> NEWS
University of Chicago researchers discovered that humans are a 'privileged' evolutionary lineage

chimpanzee.

One way to study evolution at the molecular level is to examine changes of when and where proteins are expressed in the body. "But there are many challenges to study the evolution of protein expression. Instead, we chose to track structural changes in proteins," said graduate student Eric Vallender, lead author of the article along with former graduate student Steve Dorus, both of Lahn's laboratory.

Researchers examined the DNA of 214 genes involved in brain development and function in four species: humans, macaques (an Old World monkey), rats and mice. (Primates split from rodents about 80 million years ago; humans split from macaques 20 million to 25 million years ago; and rats split from mice 16 million to 23 million years ago.)

For each of these brain-related genes, they identified changes that altered the structure of the resulting protein, as well as those that did not affect protein structure. Only those genetic changes that alter protein structure are likely to be subject to evolutionary selection, Lahn said. Changes in the gene that do not alter the protein indicate the overall mutation rate the background of random mutations from which evolutionary changes arise, known as the gene's molecular clock. The ratio of the two types of changes gives a measure of the pressure of natural selection driving the evolution of the gene.

Researchers found that brain-related genes evolved much faster in humans and macaques than in rats and mice. Additionally, the human lineage has a higher rate of protein changes than the macaque lineage. Similarly, the human lineage has a higher rate than the chimpanzee lineage.

"For brain-related genes, the amount of evolution in the lineage leading to humans is far greater than the other species we have examined," Lahn said. "This is based on an extensive set of genes."

They argue that a significant fraction of genes in the human genome were impacted by this selective process
'"/>

Contact: Catherine Gianaro
catherine.gianaro@uchospitals.edu
773-702-6241
University of Chicago Medical Center
28-Dec-2004


Page: 1 2 3 4 5

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
4. $9M grant awarded to University of Cincinnati for bipolar disorder research
5. University of Leeds strengthens China links in membrane and neurobiology
6. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
7. Manchester University helps with pharaoh DNA analysis
8. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
9. University of Arizona launches major scientific research initiative at Biosphere 2
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... 2016 Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first EU-regulated ... comfort and unbeatable security, with a Voice Biometrics ... Worldcore is the first EU-regulated global payment ...
(Date:2/3/2016)... India , February 3, 2016 ... the new market research report "Automated Fingerprint Identification System ... Search, Latent Search), Application (Banking & Finance, Government, Healthcare, ... published by MarketsandMarkets, the market is expected to be ... CAGR of 21.0% between 2015 and 2020. The transformation ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of the bioinformatic market by reviewing the recent ... enabled tools that drive the field forward. Includes ... to: Identify the challenges and opportunities that ... providers and software solution developers, as well as ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... , ... February 08, 2016 , ... ... testing services, announced today the launch of its revamped and improved website. In ... language service solutions, the redesigned website will better communicate how the company designs ...
(Date:2/9/2016)... ... February 09, 2016 , ... The publishing industry has ... publishing is one of the popular publication models that has received wider acknowledgement ... and 3000+ International Conferences across the globe, OMICS International is all ...
(Date:2/9/2016)... and LONDON , February 9, ... leading bio tech replace paper and protect ... web-based electronic laboratory notebook (ELN) will be rolled out in ... paper-based research and development (R&D) and protect valuable IP. Users ... and follow a specific researcher or experiment as part of ...
(Date:2/8/2016)... Feb. 8, 2016 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... ten finalists for clean technology companies in the TSX Venture ... 10 companies listed on the TSX Venture Exchange, in each ... clean technology & life sciences, diversified industries and ... given to return on investment, market cap growth, trading volume ...
Breaking Biology Technology:
Cached News: