University of Cincinnati receives $1.7M to research molecular treatment of brain injury

ow traumatic brain injury.

Strauss and other researchers previously found that the enzyme COX-2 is one of the contributors to harmful inflammation. COX-2 increases following injury and, to the brains detriment, remains elevated for many days.

Strauss had originally been studying the potential of the arthritis drug Vioxx, a COX-2 inhibitor, for reducing inflammation in the injured brain. But his plan was shelved when Merck withdrew Vioxx in 2004 after clinical trials showed that long-term use increased the risk of heart attack and stroke.

Strauss then shifted his focus from suppression of the harmful COX-2 enzyme to the potential for elevating two theoretically helpful eicosanoids, known as HETEs and EETs.

We believe eicosanoids reduce the number of inflammatory cells that fester around the injury site and cause chronic tissue degeneration, Strauss says. We think this plays a role in impairment not only after trauma, but also after other brain injuries, including strokes, seizures and the chronic neurodegenerative conditions like Alzheimers disease.

Strauss hypothesizes that manipulating the chemistry of the injured brain cells to favor the creation of the beneficial eicosanoids will aid recovery from traumatic brain injury.

He will first study the phenomenon in rodents that have been genetically manipulated so that they produce either an abundance or an insufficient amount of the molecules.

He will also study unique compounds, provided by colleagues at the University of Texas Southwestern Medical Center and the University of California, Davis, that boost beneficial eicosanoids that occur naturally in the brain. These compounds could set the stage for the development of drugs that would benefit traumatic brain injury patients.


Contact: Cindy Starr
University of Cincinnati

Page: 1 2

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
4. $9M grant awarded to University of Cincinnati for bipolar disorder research
5. University of Leeds strengthens China links in membrane and neurobiology
6. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
7. Manchester University helps with pharaoh DNA analysis
8. University of Arizona launches major scientific research initiative at Biosphere 2
9. Link between obesity and enlarged heart discovered by University of Arizona researchers
10. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences
11. University of Pittsburgh School of Medicine researchers develop off-the-shelf vascular grafts

Post Your Comments:

(Date:11/12/2019)... (PRWEB) , ... November 12, 2019 , ... ... Cross-Channel Spend Optimizer that improves digital advertising performance up to 25% and reduces ... Advertising, Cross-Channel Spend Optimizer uses advanced multi-touch attribution (MTA) to predict best advertising ...
(Date:11/9/2019)... ... November 08, 2019 , ... SiteSeer Technologies, creator of ... as a new client and user of SiteSeer. The boutique real estate developer of ... U.S. will use SiteSeer to supplement its own analysis of markets. , Geoffrey ...
(Date:11/6/2019)... ... November 06, 2019 , ... In October, Massachusetts stem cell ... patients about a poorly disclosed deficiency in stem cell treatments. Throughout stem ... the treating stem cells. This problem affects all patients receiving stem cell ...
Breaking Biology News(10 mins):
(Date:11/19/2019)... ... November 19, 2019 , ... Supercomputing Conference ... learning infrastructure solutions for Autonomous Vehicle , Medical Imaging, and Natural Language ... systems with the Graphcore Poplar® software stack as part of its bare-metal cloud ...
(Date:11/12/2019)... ... November 12, 2019 , ... Genedata, ... that Immatics Biotechnologies , a clinical-stage biopharmaceutical company developing T-cell receptor ... R&D operations related to the discovery and development of high-affinity and high-specificity ...
(Date:11/12/2019)... Va. (PRWEB) , ... November 12, 2019 , ... ... forensic DNA services, welcomed their new Director of Forensic Genealogy, Melinde Lutz Byrne, ... Genealogy Service (FGS) to ultimately provide investigative leads to law enforcement through ...
(Date:11/9/2019)... ... November 08, 2019 , ... ... for use in pathology research, today announced the results of analyses examining ... enrolled in the phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated ...
Breaking Biology Technology:
Cached News: