University of Cincinnati receives $1.7M to research molecular treatment of brain injury

ow traumatic brain injury.

Strauss and other researchers previously found that the enzyme COX-2 is one of the contributors to harmful inflammation. COX-2 increases following injury and, to the brains detriment, remains elevated for many days.

Strauss had originally been studying the potential of the arthritis drug Vioxx, a COX-2 inhibitor, for reducing inflammation in the injured brain. But his plan was shelved when Merck withdrew Vioxx in 2004 after clinical trials showed that long-term use increased the risk of heart attack and stroke.

Strauss then shifted his focus from suppression of the harmful COX-2 enzyme to the potential for elevating two theoretically helpful eicosanoids, known as HETEs and EETs.

We believe eicosanoids reduce the number of inflammatory cells that fester around the injury site and cause chronic tissue degeneration, Strauss says. We think this plays a role in impairment not only after trauma, but also after other brain injuries, including strokes, seizures and the chronic neurodegenerative conditions like Alzheimers disease.

Strauss hypothesizes that manipulating the chemistry of the injured brain cells to favor the creation of the beneficial eicosanoids will aid recovery from traumatic brain injury.

He will first study the phenomenon in rodents that have been genetically manipulated so that they produce either an abundance or an insufficient amount of the molecules.

He will also study unique compounds, provided by colleagues at the University of Texas Southwestern Medical Center and the University of California, Davis, that boost beneficial eicosanoids that occur naturally in the brain. These compounds could set the stage for the development of drugs that would benefit traumatic brain injury patients.


Contact: Cindy Starr
University of Cincinnati

Page: 1 2

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
4. $9M grant awarded to University of Cincinnati for bipolar disorder research
5. University of Leeds strengthens China links in membrane and neurobiology
6. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
7. Manchester University helps with pharaoh DNA analysis
8. University of Arizona launches major scientific research initiative at Biosphere 2
9. Link between obesity and enlarged heart discovered by University of Arizona researchers
10. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences
11. University of Pittsburgh School of Medicine researchers develop off-the-shelf vascular grafts

Post Your Comments:

(Date:3/4/2020)... ... March 04, 2020 , ... RoosterBio Inc., ... hMSC bioprocess systems, announces today a significant milestone in the regenerative medicine field ... The patient has been treated by RoosterBio’s pharmaceutical customer with an Investigational New ...
(Date:3/2/2020)... Md. (PRWEB) , ... March 02, 2020 , ... Nominations ... globally-recognized program co-founded by the Security Industry Association (SIA) and SecureIDNews ... SIA Women in Security Forum . The recipients of this year’s Women in ...
(Date:2/28/2020)... ... February 27, 2020 , ... Regen Suppliers is now ... rate PDO thread lift products are not only one of the only ... invasive thread lift procedures are increasing exponentially in popularity, as they represent an excellent ...
Breaking Biology News(10 mins):
(Date:3/13/2020)... , ... March 12, 2020 , ... ... the APC Microbiome Ireland SFI Research Center (APC), a pioneer in the field ... body and play a significant role in human health, based at University College ...
(Date:3/10/2020)... N.J. (PRWEB) , ... March 10, 2020 , ... Ortho ... lives through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended ... of transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max in ...
(Date:3/10/2020)... ... March 10, 2020 , ... Lifecycle Biotechnologies announced today ... Cleburne, Texas to be used as a biopharmaceutical and biotechnology production and development campus. ... offices as well as its production and development hub. The company expects to relocate ...
(Date:3/4/2020)... ... ... This month, Cognosante will make its annual appearance at the HIMSS Global Health Conference ... that align with the HIMSS annual theme, “Be the Change.” , Cognosante’s presence ... From Interoperability and HIE to Cloud Computing and BPO ...
Breaking Biology Technology:
Cached News: