HOME >> BIOLOGY >> NEWS
University of Pittsburgh discovers genetic 'shut down' trigger in healthy immune cells

PITTSBURGH, May 9 -- A fundamental genetic mechanism that shuts down an important gene in healthy immune system cells has been discovered that could one day lead to new therapies against infections, leukemia and other cancers. Results of a University of Pittsburgh School of Medicine study on the mechanism, called a somatic stop-codon mutation, are being reported today in the online journal PLoS ONE, published by the Public Library of Science.

"This kind of loss-of-function mutation can be very dangerous, and it is the first such mutation that has been identified in normal immune cells in blood," said Bora E. Baysal, M.D., Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine. "We did control experiments for two years to make sure it was real and not a technical error."

Dr. Baysal and his colleagues tested 180 samples, including blood from healthy individuals and other material from those with childhood leukemia, looking at specific portions of DNA in immune cells known as monocytes, natural killer cells and lymphocytes. These cells are key to the bodys immune response against infection and disease. The investigators found somatic stop-codon mutations in an average of 5.8 percent of crucial portions of genetic material that deliver instructions from DNA, called messenger RNA, in normal blood samples and in a quarter of leukemia samples.

"DNA is the blueprint for all living cells. It carries the genetic code for most biological functions and is passed virtually unchanged from generation to generation," said Dr. Baysal, who also is an associate investigator at the university-affiliated Magee-Womens Research Institute. "Harmful alterations in the code mutations can produce genetic disorders and play an important role in the development of cancer. Normal cells such as monocytes, lymphocytes and natural killer cells have many mechanisms to recognize and repair m
'"/>

Contact: Michele Baum
baummd@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
9-May-2007


Page: 1 2

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
4. $9M grant awarded to University of Cincinnati for bipolar disorder research
5. University of Leeds strengthens China links in membrane and neurobiology
6. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
7. Manchester University helps with pharaoh DNA analysis
8. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
9. University of Arizona launches major scientific research initiative at Biosphere 2
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2019)... , ... January 07, 2019 , ... ... and Artificial Intelligence solutions for precision health in oncology and other key therapeutic ... Morgan’s exclusive meeting of investors, entrepreneurs and executives spanning the entire healthcare landscape, ...
(Date:1/4/2019)... ... January 02, 2019 , ... ... noteworthy, as the life science tools and service supplier turned 40 in 2018 ... catalog. The catalog features not just part numbers like most catalogs, but rather, ...
(Date:12/27/2018)... ... December 27, 2018 , ... AxioMed ... its new Boston facility, and is now raising growth capital to ramp up ... market share against inferior ball and socket discs. The capital raise is targeted ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic ... interpret – has been used to convict a Wyoming man of third-degree sexual assault, ... Laboratory used STRmix™ to test for DNA on the couch cushions on which the ...
(Date:11/29/2018)... , ... November 29, 2018 , ... RAGS, today announced ... by Kickstart Seed Fund, with participation from existing investor and board member Jeremy Andrus, ... Smith of Cotopaxi. The additional funding will enable the company to accelerate its growth ...
(Date:11/27/2018)... SANDY SPRINGS, Ga. (PRWEB) , ... November 27, 2018 , ... ... GA, can now visit Dr. Dan Myers’ practice for treatment, with or without a ... of cosmetic procedures and tools, including porcelain veneers, dental implants, bridges and custom crowns. ...
(Date:11/20/2018)... (PRWEB) , ... November 19, 2018 , ... ... pleased to announce the release of the Chinese translation of Best Practices: Recommendations ... 2018, is a practice-changing publication aimed at advancing the science of biobanking to ...
Breaking Biology Technology:
Cached News: