HOME >> BIOLOGY >> NEWS
University of Washington researchers play leading role in major study of human genome function

bers, uncovering how different aspects of genome function relate to one another.

The ENCODE project has given us unprecedented insight into how functional information is organized in the human genome, said Dr. John Stamatoyannopoulos, UW professor of genome sciences, one of the leaders of the ENCODE project, and a senior author on the Nature article. The diverse nature and sheer volume of the ENCODE data enabled us for the first time to visualize how the packaging of DNA, the replication of DNA, the production of RNA, and the evolution of DNA sequences all fit together.

Each ENCODE center used a different experimental approach for mapping functional sequences within the genome. The UW ENCODE team of molecular and computational biologists focused on identifying functional elements hidden in non-gene DNA by carefully mapping how DNA is packaged in the cell nucleus. In order to fit within the nucleus, DNA is tightly wound around proteins to create a substance called chromatin. Many years ago, researchers found differences between the chromatin at gene-controlling DNA sequences and the chromatin in other areas of the genome. In these gene-controlling regions, specialized proteins latch onto DNA and unfold the chromatin, activating nearby genes.

The UW team created new methods for finding these unfolded regions within the billions of DNA bases on the genome. First, they used an inexpensive enzyme, called DNaseI, as a molecular bloodhound. When it is injected into a living cell, the enzyme seeks out regions of unfolded chromatin that correspond to functional elements. By mapping where the DNaseI traveled, the researchers created a high-resolution map of chromatin structure that pinpointed the locations of thousands of gene-controlling sequences.

To handle the massive amounts of data produced by the many ENCODE teams, Stamatoyannopoulos teamed up with Dr. William Noble, UW associate professor of genome sciences and computer scien
'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
13-Jun-2007


Page: 1 2 3

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
4. $9M grant awarded to University of Cincinnati for bipolar disorder research
5. University of Leeds strengthens China links in membrane and neurobiology
6. University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
7. Manchester University helps with pharaoh DNA analysis
8. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
9. University of Arizona launches major scientific research initiative at Biosphere 2
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... announced today that they have entered into a multiyear collaboration to identify and ... researchers with additional tools for gene editing across all applications. , Under the ...
(Date:10/12/2017)... ca (PRWEB) , ... October 12, 2017 , ... ... the Surgical Wound Market with the addition of its newest module, US Hemostats ... $1.2B market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
Breaking Biology Technology:
Cached News: