HOME >> BIOLOGY >> NEWS
Unlocking proteins from their cellular shell

PHILADELPHIA Applying physical stress to cells, researchers at the University of Pennsylvania have demonstrated that everyday forces can alter the structure of proteins tucked within cells, unfold them and expose new targets in the fight against disease.

The findings for both simple red blood cells and more versatile stem cells show that hidden and folded parts of proteins can be exposed by physical strain, not just by chemical reaction. From there, proteins can be labeled and mapped, increasing the understanding of cellular behavior and unlocking novel targetable sites for drugs that might interact with these active proteins to treat disease.

The study appears in the current issue of the journal Science.

Cells are exposed to forces every minute of every day. Some forces are exerted by the flow of bodily fluids, such as blood streaming through arteries, while other forces are generated by cells as they crawl and contract in tissue. Penn researchers used force to induce changes in the structures of cytoskeletal proteins and, employing fluorescent dyes, labeled proteins sequentially, visualized them, and molecularly pinpointed the newly exposed parts of proteins. By forcing proteins to unfold, hidden binding sites were thus revealed. Multicolor maps were generated that revealed locations of protein sites not accessible when the cell remained static and relaxed.

"We were motivated to probe molecular mechanics within cells in part by our recent findings on stem cells that show they generate their own forces, switching on and off development of different cell types," Dennis Discher, professor of chemical and biomolecular engineering at Penn, said.

Proteins are the molecular instigators for almost every biologic action and reaction in living things. Their assembly and reactions are the foundation of processes from the division of cells to the complex chain of events that result in the apparently simple blink of an eye. Path
'"/>

Contact: Jordan Reese
jreese@pobox.upenn.edu
215-573-6604
University of Pennsylvania
2-Aug-2007


Page: 1 2

Related biology news :

1. Unlocking mysteries of brain, grooming future med students goals of UH prof
2. Unlocking genetic mysteries focus of UH symposium
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Call for EU to launch major project to map out all our proteins
6. MIT IDs link between brain tumor proteins
7. Protein pulling -- Learning how proteins fold by pulling them apart
8. Measuring the unseeable: Penn researchers probe proteins dark energy
9. New use for a cell toxin found to inhibit survival proteins in cancer cells
10. Pairing nanoparticles with proteins
11. Targeting key proteins of carcinogenesis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... 2020 , ... Mosio recently announced its newly updated text ... of all sizes. With a focus on tracking symptoms and monitoring outbreaks as ... Mosio helps public health departments automate communications and provide more personalized care and ...
(Date:8/3/2020)... ... 03, 2020 , ... Accumen Inc. is helping healthcare get ... Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has ... than 10 years. Early in the COVID-19 crisis, we identified supply chain gaps ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... ... that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise control device ... The study reported that the Neoasis™ device attenuated the alarm sounds from patient ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:7/31/2020)... , ... July 29, 2020 , ... R3 Stem Cell ... for only $3950. With 50 million stem cells total, patients may choose which extremities ... therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord ...
(Date:7/31/2020)... N.J (PRWEB) , ... July 29, 2020 , ... ... company, and Catalent, the leading global provider of advanced delivery technologies, development, and ... today announced that they have entered into a strategic partnership whereby Catalent will ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , ... Solutions, in a one hour live webinar on Thursday, August 13, 2020 ... for drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing ...
Breaking Biology Technology:
Cached News: