HOME >> BIOLOGY >> NEWS
Unlocking proteins from their cellular shell

PHILADELPHIA Applying physical stress to cells, researchers at the University of Pennsylvania have demonstrated that everyday forces can alter the structure of proteins tucked within cells, unfold them and expose new targets in the fight against disease.

The findings for both simple red blood cells and more versatile stem cells show that hidden and folded parts of proteins can be exposed by physical strain, not just by chemical reaction. From there, proteins can be labeled and mapped, increasing the understanding of cellular behavior and unlocking novel targetable sites for drugs that might interact with these active proteins to treat disease.

The study appears in the current issue of the journal Science.

Cells are exposed to forces every minute of every day. Some forces are exerted by the flow of bodily fluids, such as blood streaming through arteries, while other forces are generated by cells as they crawl and contract in tissue. Penn researchers used force to induce changes in the structures of cytoskeletal proteins and, employing fluorescent dyes, labeled proteins sequentially, visualized them, and molecularly pinpointed the newly exposed parts of proteins. By forcing proteins to unfold, hidden binding sites were thus revealed. Multicolor maps were generated that revealed locations of protein sites not accessible when the cell remained static and relaxed.

"We were motivated to probe molecular mechanics within cells in part by our recent findings on stem cells that show they generate their own forces, switching on and off development of different cell types," Dennis Discher, professor of chemical and biomolecular engineering at Penn, said.

Proteins are the molecular instigators for almost every biologic action and reaction in living things. Their assembly and reactions are the foundation of processes from the division of cells to the complex chain of events that result in the apparently simple blink of an eye. Path
'"/>

Contact: Jordan Reese
jreese@pobox.upenn.edu
215-573-6604
University of Pennsylvania
2-Aug-2007


Page: 1 2

Related biology news :

1. Unlocking mysteries of brain, grooming future med students goals of UH prof
2. Unlocking genetic mysteries focus of UH symposium
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Call for EU to launch major project to map out all our proteins
6. MIT IDs link between brain tumor proteins
7. Protein pulling -- Learning how proteins fold by pulling them apart
8. Measuring the unseeable: Penn researchers probe proteins dark energy
9. New use for a cell toxin found to inhibit survival proteins in cancer cells
10. Pairing nanoparticles with proteins
11. Targeting key proteins of carcinogenesis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2020)... ... May 29, 2020 , ... eInfochips, a leading provider of ... with EchoNous Inc. to develop the cloud-based connected health KOSMOS platform that has ... has been clinically tested versus expert measurements, yielding improved results in precision and ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... announced that Gritstone Oncology, Inc., a clinical-stage biotechnology company developing cancer immunotherapies, ... TCR-based therapeutics, has implemented Genedata Biologics ® within their R&D organization. ...
(Date:5/21/2020)... ... May 20, 2020 , ... Law Enforcement has always ... for all of us. The positions of these men and women put them constantly ... for not following rules precisely. Officers have always had to face very high daily ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... , ... June 22, 2020 , ... ... offering an Amniosomes special offer. This includes buy three, get the fourth unit ... (888) 568-6909. , Amniotic derived exosomes, known as exosomes, have been a game ...
(Date:6/19/2020)... , ... June 18, 2020 , ... The Vitaspace ... goal is to join forces to radically prolong life and find a way (medicine ... aging period. This project was supported by various scientists from all over the world, ...
(Date:6/11/2020)... ... 09, 2020 , ... TRX Systems, developer of NEON® Indoor ... a highly accurate, contact tracing solution for identification of employees who may have ... disease control measure, is a key strategy for preventing further spread of COVID-19. ...
(Date:6/2/2020)... ... June 01, 2020 , ... As part of its ongoing ... the world, enterprise security solutions provider bitsIO donated time to help two companies ... during self-quarantines and shelter-in-place orders, companies are increasingly concerned about the security of ...
Breaking Biology Technology:
Cached News: