HOME >> BIOLOGY >> NEWS
Unraveling the viral mechanism

Using powerful computer tools and cryo-electron microscopes, researchers at Baylor College of Medicine unmasked the secrets of a tiny virus that infects bacteria and, in doing so, opened the door to a better understanding of a variety of viruses that infect people and animals.

In a report that appears in and on the cover of the current issue of the journal Nature, Dr. Wah Chiu, professor in the BCM department of biochemistry and molecular biology and director of the National Center for Macromolecular Imaging, and his colleagues, describe how they were able to look beyond the highly symmetrical ball-like surface protein shell of the episilon15 bacteriophage that infects Salmonella bacteria and describe different molecular parts involved in binding to host cells, injecting DNA into the cell and packaging it during the virus formation.

"This methodology, in theory, can be applicable to other kinds of human viruses," said Chiu. In fact, he said, this bacteriophage appears structurally similar although smaller than the herpes simplex virus, which causes cold sores and related infections. That means it should be possible to use these tools to understand better how this and similar viruses infect nerve cells and, some day, interrupt that disease process.

The advance occurred because of innovations in computational method development in addition to the powerful cryoelectron microscopes operated at very low specimen temperature and very high energy that Chiu and others use in their work that looks at different biological nano-machineries at the nanoscale.

In fact, Dr. Wen Jiang, previously trained in the BCM Graduate School for Biomedical Sciences' Graduate Program in Structural and Computational Biology and Molecular Biophysics (SCBMB), developed a new image reconstruction algorithm. These developments enabled him and his co-authors at MIT to see through the bacteriophage at very high resolution. "It turns out that, in addition to the surfa
'"/>

Contact: Kimberlee Barbour
kbarbour@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
1-Feb-2006


Page: 1 2

Related biology news :

1. Unraveling the physics of DNAs double helix
2. Unraveling where chimp and human brains diverge
3. Unraveling Alzheimers: Clues may be found visualizing plaques in human brain, mad cowtype diseases
4. Unraveling a stomach cancer puzzle
5. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
6. K-State biologist hopes mosquito can break viral chain
7. Vaccine to cope with viral diversity in HIV
8. Kansas State study finds new vaccine effective against deadly viral disease affecting swine
9. Antiretroviral resistance testing in HIV infected patients improves health and saves costs
10. Common mechanisms for viral DNA replication
11. Hundreds of thousands of viral species present in the worlds oceans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... Mass. (PRWEB) , ... August 18, 2020 , ... ... approaches to cell therapy, today announced that the U.S. Food and Drug Administration ... of Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval of ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary to ... Roche and J&J have annual Research and Development spending in excess of US ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from the Centers ... making them the first Wharton’s jelly allografts to be assigned a Q code and ... are the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign ... detection and prevention of high-burden diseases, and Centric Consulting, a business and technology ... to utilize existing data in order to identify and prioritize patients for care. ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its ... the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... today announced that the launch of a new clinical diagnostics immuno-oncology ... the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids ...
Breaking Biology Technology:
Cached News: