HOME >> BIOLOGY >> NEWS
Unstable leukemia stem cells may predispose patients to drug resistance

The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute.

Treatment with imatinib causes clinical remissions in most patients with chronic myeloid leukemia, but relapses are common and the cancer can become resistant to the drug. The oncogene, BCR-ABL, is the cause of chronic myeloid leukemia. Researchers have hypothesized that the relapses are due to chronic myeloid leukemia stem cells with specific BCR-ABL gene mutations that make them resistant to the drug long before they are exposed to it.

Xiaoyan Jiang, M.D, Ph.D., and Connie Eaves, Ph.D., of the British Columbia Cancer Agency in Vancouver, and colleagues isolated chronic myeloid leukemia stem cells from patients and analyzed them to identify mutations in the BCR-ABL gene.

The stem cells were found to be genetically unstable and had a high frequency of mutations, even in the absence of imatinib. The researchers identified more than 70 BCR-ABL mutations in the stem cells and their immediate progeny, many of which would be expected to alter the BCR-ABL proteinthe target of imatinib. This could result in resistance to the drug.

Although this study was not designed to identify mutations that would contribute to disease progression, our results suggest that these would also be found. These considerations highlight the importance of gaining further understanding of the control of DNA replication and repair in the leukemic stem cells from patients with chronic phase [chronic myeloid leukemia] in future efforts to devise therapies with curative potential, the authors write.

In an accompanying editorial, Margret Rodrigues, Ph.D., and Martin Sattler, Ph.D., of the Dana Farber Cancer Institute in Boston, discuss the possible causes of gen
'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
1-May-2007


Page: 1 2

Related biology news :

1. Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
2. Scientists gain important insights into acute promyelocytic leukemia
3. Modular leukemia drug shows promise in early testing
4. Researchers discover inherited mutation for leukemia
5. Inherited genes linked to toxicity of leukemia therapy
6. Tree rings show elevated tungsten coincides with Nevada leukemia cluster
7. Cancer scientists create human leukemia process to map how disease begins, progresses
8. Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
9. Knocking out survival protein could aid leukemia treatment
10. Massey researchers induce cell death in leukemia
11. Progress toward a targeted therapy for a specific form of leukemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... ... May 07, 2019 , ... ... been accepted into Forbes Technology Council, an invitation-only community for world-class CIOs, ... is a full-service biopharmaceutical cold chain engineering firm that guarantees confidence in ...
(Date:5/7/2019)... LONDON (PRWEB) , ... May 07, 2019 , ... ... the world’s first on-site Legionella DNA test in the UK. , In May, ... accurate qPCR Legionella results in 45 minutes, enabling operators to take corrective action ...
(Date:5/2/2019)... ... May 01, 2019 , ... uBiome, ... appointed John Rakow, the Company’s General Counsel, as Interim Chief Executive Officer of ... are currently on administrative leave. There will also be an independent investigation into ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, ... (DF). Urandir detailed the results of some research carried out by the association, ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current ... and food industries. Access to all webinars is free, so be sure to register ... field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS ...
(Date:4/25/2019)... FRANCISCO (PRWEB) , ... April 24, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced global availability ... center software providers and enterprises of all sizes to harness the power of ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., ... $2 million bench plant expansion to increase production of methylene malonate monomers and ... and construction of Sirrus’ full-scale production facility, which is scheduled to break ground ...
Breaking Biology Technology:
Cached News: