HOME >> BIOLOGY >> NEWS
Unusual RNAs linked to chronic leukemia, may help treat it

COLUMBUS , Ohio A new and unusual class of genes plays an important role in the development of chronic lymphocytic leukemia (CLL), according to new research here. At the same time, these genes may provide a new form of therapy for the disease.

CLL strikes some 9,700 Americans annually, making it the most common adult leukemia in the world.

The study found that the loss of two genes for producing small molecules known as microRNAs enables damaged cells to survive, rather than normally self-destructing before they become cancerous.

"Our findings show that microRNA genes are involved in the development of CLL," says principal investigator Carlo M. Croce, professor and chair, Department of Molecular Virology, Immunology and Medical Genetics at Ohio State, and director of the Human Cancer Genetics Program at the OSU Comprehensive Cancer Center. "They also strongly suggest that microRNAs might be used therapeutically for CLL and probably other cancers."

The research is published online in the current issue of the Proceedings of the National Academy of Science.

The two microRNA genes are known as miR-15 and miR-16. Earlier work led by Croce showed that about 65 percent of CLL patients have cancer cells that show the loss of, or damage to, these genes.

This study shows that the two microRNAs interact closely with a protein known as Bcl-2. That protein stops cells from self-destructing through a natural process known as apoptosis. (In 1984, Croce led the research that discovered the Bcl-2 gene.)

In CLL cells and cells from other kinds of cancer, the Bcl-2 protein is present in abnormally high levels. This prevents the malignant cells from self-destructing as they should and leads to tumor growth. In about 95 percent of CLL cases, scientists did not know why Bcl-2 was present at high levels. The current paper now answers that.

Croce and his colleagues discovered that the miR-15 and miR-16 microRNAs play
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
12-Sep-2005


Page: 1 2

Related biology news :

1. Unusual three-drug combo inhibits growth of aggressive tumors
2. Unusual data shed new light on brain and inhibiting behavior
3. Unusual mechanism keeps repair protein accurate
4. Unusual antibiotics show promise against deadly superbugs
5. Unusual reproductive behavior of odd ants surprises scientists
6. Protein chatter linked to cancer activation
7. Risk of common vaginal infection linked to preterm birth appears higher for blacks
8. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
9. Antibody linked to MS significantly higher in spinal fluid of blacks
10. Loss of cells antenna linked to cancers development
11. Scientists identify first gene linked to scoliosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... August 13, 2018 , ... NRD, LLC – NRD® is ... Ionizing Gun. , The ionizing gun features ergonomic design and rugged construction. ... filter and electropolished OSHA-compliant tip. This can be cleanroom packaged (P-2021-5502) or normally ...
(Date:8/14/2018)... ... August 14, 2018 , ... From ... movie “Wonder,” to a better understanding of congenital heart defects, 3-D printing is ... the latest special issue of Birth Defects Research (DOI: 10.1002/bdr2.1367). ...
(Date:8/7/2018)... ... 06, 2018 , ... Nurse practitioners and ... their healthcare careers in the past year, according to the second annual survey ... jobseekers with a wide variety of career- and employment-related resources including physician/candidate database, ...
Breaking Biology News(10 mins):
(Date:7/24/2018)... ... ... R3 Stem Cell is now offering regenerative therapies for COPD lung disease ... Certified providers, with outcomes significantly improving patient quality of life. , Traditional therapies for ... help repair and regenerate damaged lung tissues. Stem cell therapy for COPD ...
(Date:7/24/2018)... ... 24, 2018 , ... On August 6, 2018, BioMedGPS will ... Not just a pretty face, SmartTRAK 3.0’s latest improvements were inspired by its ... world’s first online and real-time data portal that specializes in providing competitive market ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech ... with Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under ... SkQ1 with approximately $17m allocated towards the first Phase 3 study starting as ...
(Date:7/22/2018)... ... July 20, 2018 , ... ... automation and IT solutions with 150 employees on both the east and west ... Program. Superior Controls met the high criteria for application expertise, operational excellence ...
Breaking Biology Technology:
Cached News: