HOME >> BIOLOGY >> NEWS
Unusual mechanism keeps repair protein accurate

Columbus , Ohio -- Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.

The protein, called DNA polymerase lambda, is one of a group of proteins known as DNA polymerases that are vital for accurately making and repairing DNA.

But while other DNA-repair proteins insure their accuracy with the help of so-called proof-reading regions or accessory molecules, this protein maintains its accuracy using an otherwise ordinary-looking portion of its molecular structure.

The study was led by Zucai Suo, assistant professor of biochemistry and a researcher with the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The research, published in the July 14 issue of The Journal of Biological Chemistry, provides new insights into how cells repair damaged DNA.

"DNA is constantly attacked and damaged by a variety of agents," Suo says. "The body must properly repair that damage, or it can lead to cell death or to cancer, birth defects and other diseases.

"There are six families of DNA polymerases," Suo says, "and this is the first polymerase to use this mechanism to maintain its accuracy when making new DNA. It is both surprising and unprecedented."

The repair protein itself was first discovered by scientists studying DNA sequence data produced by the Human Genome Project. Suo and his colleagues then became interested in learning how the repair protein worked.

The protein has four distinct regions, or domains. Three of the regions had molecular structures that strongly suggest the task they performed.

For example, regions three and four closely resemble a well-known repair protein called DNA polymerase beta. In fact, it was this similarity that tipped off scientists that the new protein was probably involved in DNA r
'"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
25-Jul-2006


Page: 1 2 3

Related biology news :

1. Unusual three-drug combo inhibits growth of aggressive tumors
2. Unusual data shed new light on brain and inhibiting behavior
3. Unusual RNAs linked to chronic leukemia, may help treat it
4. Unusual antibiotics show promise against deadly superbugs
5. Unusual reproductive behavior of odd ants surprises scientists
6. Weizmann Institute scientists discover a control mechanism for metastasis
7. New mechanism links smoking to lung damage
8. Identified mechanism in the malaria parasite to help it adapt to infected individuals
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. A new plant-bacterial symbiotic mechanism promising
11. MIT IDs mechanism behind fear

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 19, 2020 , ... ... and expo uniting life science, data science, informatics and IT leaders goes VIRTUAL ... this period of uncertainty and change, Bio-IT takes the leadership role of keeping ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers ... Scholar Program, a unique professional development program that provides advanced STEM (science, technology, ... science teachers nationwide. , Created in partnership between the National Stem Cell Foundation ...
(Date:7/22/2020)... ... July 21, 2020 , ... ... innovation in technology and compliance, announces a new solution to manage regulated workloads ... every layer of their technology stack complies with FDA and global regulations. USDM's ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... (PRWEB) , ... July 22, 2020 , ... Join experts ... John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... the regulating body in China for drugs and medical devices. Specifically, for medical devices, ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its ... the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as ...
(Date:7/1/2020)... GREEN, Ohio (PRWEB) , ... June 29, 2020 ... ... that offers access to competitively procured purchasing contracts to its membership, recently named ... to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, ...
Breaking Biology Technology:
Cached News: