HOME >> BIOLOGY >> NEWS
Unusual three-drug combo inhibits growth of aggressive tumors

An experimental anti-cancer regimen combined a diuretic, a Parkinson's disease medication and a drug ordinarily used to reverse the effect of sedatives. The unusual mixture inhibited the growth of aggressive prostate tumors in laboratory mice in research conducted at Washington University School of Medicine in St. Louis.

Although their drug choices may seem capricious, the researchers weren't randomly pulling drugs from their shelves. They made their discovery using sophisticated methods for delving into the unique metabolism of cancer cells and then choosing compounds likely to interfere with their growth.

"This study, led by Joseph Ippolito, a very talented M.D./Ph.D. student, demonstrates the importance of looking at tumor metabolism," says senior author Jeffrey I. Gordon, M.D, director of the Center for Genome Sciences at the School of Medicine. "Using a broad array of technology, we've obtained a view of the tumor cells' metabolome (the set of small-molecule metabolites found within cells) and revealed aspects that were not expected and could be exploited."

The findings, published in a recent article in the Proceedings of the National Academy of Sciences, expand upon earlier work by the research group, which demonstrated that aggressive types of neuroendocrine tumors - seen in some types of lung, thyroid and prostate cancers - produce high amounts of a chemical called GABA, a neurotransmitter.

Because of the abundance of GABA in these tumors, the authors previously proposed that the chemical could potentially serve as a marker for poor-prognosis neuroendocrine tumors. But the latest findings also show that the techniques used to decipher the biochemistry of the tumors can effectively be applied to seek drugs that will affect tumor metabolism.

The techniques link DNA microarray technology - which can pinpoint highly active genes in the tumors - to precise measurements of abundant metabolites and their potential byp
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
7-Sep-2006


Page: 1 2 3

Related biology news :

1. Unusual data shed new light on brain and inhibiting behavior
2. Unusual mechanism keeps repair protein accurate
3. Unusual RNAs linked to chronic leukemia, may help treat it
4. Unusual antibiotics show promise against deadly superbugs
5. Unusual reproductive behavior of odd ants surprises scientists
6. Dramatic results from combo therapy surprises Krabb-disease researchers
7. Drug combo may reduce protease inhibitor-related hardening of the arteries
8. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
9. Gene therapy inhibits epilepsy in animals
10. Antibiotic inhibits cancer gene activity
11. Activation of microRNA inhibits cancer gene in human cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... , ... KICVentures announced today its plans to host an event ... ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. The event will ... the 3rd floor Ticino Hospitality room in space #74T. , The event will feature ...
(Date:6/11/2019)... Ind. (PRWEB) , ... June 10, 2019 , ... Improved ... in the July 2019 issue of AAPS PharmSciTech. The article was published online on ... of Improved Pharma, along with Xiaoming Sean Chen of Purdue University. , The ...
(Date:6/6/2019)... ... June 05, 2019 , ... ... the exclusive financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition ... anatomic pathology platform that provides services to more than one dozen hospitals and ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... , ... May 16, 2019 , ... ... mixtures. As a result, food and beverage products rely on these ingredients to ... more natural sounding label declarations. This paradigm shift triggers food formulators to seek ...
(Date:5/8/2019)... , ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the ... in a drill team and barrel racing, among other activities. When loping around a ... He went from being a busy horse to only being able to walk. Fortunately ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the ... ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) protocol ... that 6.3 million Americans will have glaucoma, with black Americans having the highest ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading experts ... so be sure to register today to save your place! Participate in the discussion ... upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – The ...
Breaking Biology Technology:
Cached News: