HOME >> BIOLOGY >> NEWS
Unusual three-drug combo inhibits growth of aggressive tumors

roducts within intact tumor cells using nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. Software programs take this information and provide testable predictions about how these substances might drive the special metabolism of cancerous cells.

Investigating experimental mice that develop metastatic tumors of the prostate's neuroendocrine cells, the researchers discovered that the tumor cells relied on molecules that transmit signals between neurons. They found that the tumor cells respond to GABA as well as to two other neurotransmitters, glycine and glutamate.

"The question was, 'What are these neural signaling molecules doing in tumor cells found outside the central nervous system?'" says lead author Joseph E. Ippolito, a member of the University's NIH-supported M.D./Ph.D. Medical Scientist Training Program.

The researchers demonstrated that the tumor cells have receptors on their surface that recognize these neurotransmitters and are activated by them. In addition, the tumor cells directly convert GABA and glutamate into sources of energy. Moreover, glycine was involved in a mechanism that increased the amount of fatty acids - an important source of energy - in the bloodstream of the lab mice.

"We showed that the neurotransmitters GABA, glycine and glutamate not only stimulate proliferation of the tumor cells, but they also are able secure sources of energy for the cells," Ippolito says. "In a way, the tumor cells eat their own words."

Having identified a key vulnerability in these aggressive neuroendocrine tumor cells, the researchers looked for a way to exploit it. They selected agents already approved for medical use by the Food and Drug Administration.

Two drugs - amiloride, a diuretic, and carbidopa, used to treat Parkinson's disease - exert their effects by inhibiting the very same mechanisms the research group had identified as important for the tumor cells' energy-gathering reaction
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
7-Sep-2006


Page: 1 2 3

Related biology news :

1. Unusual data shed new light on brain and inhibiting behavior
2. Unusual mechanism keeps repair protein accurate
3. Unusual RNAs linked to chronic leukemia, may help treat it
4. Unusual antibiotics show promise against deadly superbugs
5. Unusual reproductive behavior of odd ants surprises scientists
6. Dramatic results from combo therapy surprises Krabb-disease researchers
7. Drug combo may reduce protease inhibitor-related hardening of the arteries
8. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
9. Gene therapy inhibits epilepsy in animals
10. Antibiotic inhibits cancer gene activity
11. Activation of microRNA inhibits cancer gene in human cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... , ... June 25, 2020 , ... In an upcoming ... innovations in accelerated Point of Care Testing solutions (POCT). Check local listings for more ... collected at medical offices and are shipped to labs throughout the country. Results are ...
(Date:6/23/2020)... (PRWEB) , ... June 22, 2020 , ... The field ... Typically, ligand binding assays (LBA) have dominated this area. However, the use of mass ... years. , This now necessitates the question “How do you choose which approach to ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and ... how to integrate and automate cutting-edge scientific instruments and laboratory equipment from ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 22, 2020 , ... ... Amniosomes special offer. This includes buy three, get the fourth unit free with ... , Amniotic derived exosomes, known as exosomes, have been a game changer for ...
(Date:6/19/2020)... , ... June 18, 2020 , ... The Vitaspace ... goal is to join forces to radically prolong life and find a way (medicine ... aging period. This project was supported by various scientists from all over the world, ...
(Date:6/11/2020)... Md. (PRWEB) , ... June 09, 2020 , ... ... today the release of the NEON Micro-Tracer Solution, a highly accurate, ... the COVID-19 virus in the workplace. Contact tracing, a core disease control measure, ...
(Date:6/2/2020)... (PRWEB) , ... June 01, 2020 , ... ... hand to companies and encourage positive change in the world, enterprise security solutions ... pandemic. , With more people working from home during self-quarantines and shelter-in-place orders, ...
Breaking Biology Technology:
Cached News: