HOME >> BIOLOGY >> NEWS
Uric acid and spinal cord injury treatment

s, the addition of uric acid reduces symptoms and improves prognosis. The same is true for one type of Parkinson's disease tested."

The Firestein team's breakthrough studies revealed that uric acid can stimulate astroglial cells to produce transporter proteins that carry harmful compounds away from neurons in jeopardy of chemical damage. This opens the door to identifying a unique drug target for new therapies.

Glutamate is a compound that under normal circumstances aids neurons in transmitting signals for cognitive functions in the brain, such as learning and memory. In the case of spinal cord injury or stroke where there is physical cell damage, however, an excess of glutamate is released and it accumulates around the remaining intact neurons, eventually choking them to death.

When Firestein's group added uric acid to a mixed culture of rat spinal cord neurons and astroglial cells, the production of the glutamate transporter EAAT-1 increased markedly. The challenge now is find the most effective strategy for increasing the production of the transporter, using drug therapies or other means.

Firestein said that a collaborative team of colleagues from Baylor College of Medicine and the University of Rochester Medical Center has devised one such strategy. With this team, Firestein will develop a line of stem cells that has been modified to generate astrocytes that produce large quantities of the EAAT-1 transporter. Adding these to an injury site, either alone or in combination with uric acid, holds great potential, she said.


'"/>

Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers, the State University of New Jersey
3-Jan-2007


Page: 1 2

Related biology news :

1. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
2. Antibody linked to MS significantly higher in spinal fluid of blacks
3. Remicade data in ankylosing spondylitis show improvement in spinal mobility and spinal inflammation
4. Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinsons disease
5. CSHL shows correcting RNA splicing may help treat spinal muscular atrophy
6. Treatment extends survival in mouse model of spinal muscular atrophy
7. Pourqui Lab clarifies mode of formation of spinal precursors
8. Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
9. Thinking with the spinal cord?
10. In young rats, researchers find a reaction to spinal cord injury that speeds recovery
11. Study establishes safety of spinal cord stem cell transplantation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... , ... August 06, 2020 , ... ... industry, is pleased to announce that Eric Chen and Jessica Wong have joined ... Product Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead upcoming ... term focus on Type 2 diabetes and associated comorbidities. , Justin brings over ... and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... ... ... fast-growing provider of cloud-based software for the life sciences industry, today announced ... and presentation platform designed specifically for Medical Science Liaisons (MSLs) and other ...
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
Breaking Biology Technology:
Cached News: