Pseudouridylation is one of the most abundant forms of post-transcriptional RNA modification in eukaryotes and archaea, and plays a key role in the generation and correct functioning of cellular RNAs. The modifications are made by a complex of proteins directed to target sites by integral non-coding guide RNAs. Drs. Michael and Rebecca Terns and colleagues have effectively reconstituted the archaeal modification guide ribonucleoprotein complex that guides pseudouridylation in vitro in a site-specific manner. This study provides unprecedented insight into the organization and function of pseudouridylation guide RNPs, and Dr. Terns indicates that "this is only the beginning of the gold mine of new information that this system will yield about a complex that is also involved in rRNA processing and the function of telomerase in eukaryotes."
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
2-May-2005


Page: 1
Related biology news :

1. Using stem cells to help heart attack victims
2. Using Nanotechnology to Improve Health Care in Developing Countries
3. Using science and agriculture to achieve sustainable investments in the new bioeconomy
4. Using an activated-carbon filtering pitcher significantly reduces chemicals in tap water
5. Using chemistry to predict the dynamics of clotting in human blood
6. Using microbes to fuel the US hydrogen economy
7. Using natures most primitive anti-viral defense system to find new approaches to cancer research
8. A step toward halting Alzheimers: Using FDDNP PET to detect disease progression, MCI
9. Using satellite observations to study photosynthetic trends in northern circumpolar high latitudes
10. Using stem cells to repair torn tendons
11. Using minutiae to match fingerprints can be accurate