HOME >> BIOLOGY >> NEWS
Uterine cancer may be clue to inherited syndrome

COLUMBUS , Ohio -- A new study suggests that women with endometrial cancer should be screened for inherited mutations that could lead to a high risk of several other cancers.

The study showed that 1.8 percent, or about one in 50, of newly diagnosed endometrial cancer patients have mutations for Lynch syndrome, an inherited condition also known as hereditary nonpolyposis colon cancer, or HNPCC.

People with Lynch syndrome mutations are at high risk for colon, endometrial, ovarian and gastric cancer. Endometrial, or uterine, cancer is the most common cancer in women with this condition.

The study, led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), is published in the Aug. 1 issue of Cancer Research.

The study is the first to comprehensively screen a large number of women with uterine cancer for Lynch syndrome mutations, said Heather Hampel, a genetic counselor in the clinical cancer genetics program and first author of the study.

"It's important to identify women with one of these mutations because they have a very high risk for developing colon cancer, and they may not be aware of that risk," said Hampel. "Because this is hereditary, half of her siblings and children may also be at risk for the syndrome.

"For this reason, the relatives of a person with Lynch syndrome should also be screened for the responsible gene mutation," said Hampel, a clinical assistant professor in the department of internal medicine.

Family members who also have the mutation need close monitoring for early cancer detection, including an annual colonoscopy starting at age 25 and endometrial cancer screening (using ultrasounds and biopsies) starting at age 30, Hampel said.

Family members without the mutation can follow the American Cancer Society's guidelines for colorectal cancer screening,
'"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University
2-Aug-2006


Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Newly created cancer stem cells could aid breast cancer research
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. No evidence that widely prescribed statins protect against prostate cancer
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. New study suggests Concord grape juice may provide protection against breast cancer
8. New test improves detection of liver cancer
9. High-intensity ultrasound may launch attack on cancer, wherever it lurks
10. Unknotting DNA clue to cancer syndrome
11. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... CAMBRIDGE, Mass. (PRWEB) , ... August 28, 2018 ... ... QipWorks, today introduced an annual awards program that recognizes women of excellence in ... recipient. , Sponsored by QipWorks, the Johanna Dwyer Women in IP Award aims ...
(Date:8/26/2018)... , ... August 23, 2018 , ... ... has for increased sensitivity and specificity over more commonly used analytical techniques. However, ... the added burden of development and validation of methods that must be undertaken ...
(Date:8/23/2018)... ... August 21, 2018 , ... Mandy is an eight-year-old mini Australian shepherd and a tripod. When ... She went through three surgeries to try to repair the leg and each time it ... leg so her owner, along with her veterinarian, decided to amputate. With only one ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... September 06, 2018 , ... The Discovery on Target ... of “The industry’s preeminent event on novel drug targets.” BellBrook Labs’ high throughput ... study these emerging targets in a quest to find new treatments for disease. ...
(Date:9/1/2018)... , ... August 31, 2018 , ... ... results of the impact of a proprietary biofield energy treated nutraceutical supplement used ... biomarkers for immune function response and blood, as well as, organ-specific inflammation. The ...
(Date:8/29/2018)... LEXINGTON, Mass. (PRWEB) , ... August 28, 2018 , ... ... is announcing the full lineup of talks for NAVIGATE2018 . , Ryan ... NAVIGATE2018 , Cognition’s annual user conference. An experienced engineer and manager with Zimmer ...
(Date:8/29/2018)... ... August 28, 2018 , ... USDM Life Sciences , the leading risk ... industries, announces that Manu Vohra will deliver a presentation at the BoxWorks 2018 ... Implement Box for GxP in 30 Days” , When: Thursday, August 30, 1:00-1:50 PM ...
Breaking Biology Technology:
Cached News: