HOME >> BIOLOGY >> NEWS
Uterine cancer may be clue to inherited syndrome

which call for a colonoscopy every 10 years starting at age 50 and no routine endometrial cancer screening, she said.

This study involving 543 women was led by Albert de la Chapelle, co-leader of the OSUCCC Molecular Biology and Cancer Genetics Program. Participants in the study were diagnosed and treated for endometrial cancer at the three major hospital systems in Columbus, Ohio, between 1999 and 2003.

To learn the frequency of Lynch syndrome mutations among all newly diagnosed endometrial cancer patients, the researchers tested tissue from the tumors from each patient for MSI (microsatellite instability), a change in the DNA of tumor cells that occurs in more than 90 percent of Lynch syndrome tumors. Of the 543 tumors tested, 118 showed MSI. Because these patients are more likely to have Lynch syndrome, they participated in the gene testing portion of the study and nine (1.8 percent) were found to have Lynch syndrome mutations.

In addition, the researchers used another technique called immunohistochemistry, to prescreen the tumors for mutations. Follow-up gene testing performed on patients with abnormal immunohistochemistry results showed that one additional woman with an MSI-negative tumor also had a Lynch syndrome mutation.

Of the 10 Lynch syndrome patients, seven did not meet the usual criteria for diagnosing the hereditary condition. That diagnosis is largely based on family history and age. Ordinarily, these seven cases would have gone undiagnosed.

In addition, the counseling and testing of 21 relatives of the 10 women with Lynch syndrome revealed 10 additional people with Lynch syndrome mutations.

The study is the continuation of an Ohio State colon cancer study also led by de la Chapelle that was published in the New England Journal of Medicine in 2005. In that study, 2.2 percent of newly diagnosed colon cancer patients tested positive for Lynch syndrome.

That study recommended te
'"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University
2-Aug-2006


Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Newly created cancer stem cells could aid breast cancer research
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. No evidence that widely prescribed statins protect against prostate cancer
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. New study suggests Concord grape juice may provide protection against breast cancer
8. New test improves detection of liver cancer
9. High-intensity ultrasound may launch attack on cancer, wherever it lurks
10. Unknotting DNA clue to cancer syndrome
11. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... ... December 10, 2018 , ... Today, RoosterBio Inc. and Tissue ... of accelerating the development of the Regenerative Medicine field. This alliance will ... around human umbilical cord perivascular cells (HUCPVCs). Together, it is anticipated that ...
(Date:12/5/2018)... British Columbia (PRWEB) , ... December 05, 2018 ... ... The Royal Society of Medicine’s Photodynamic Therapy symposium 2018, London, England. The 2018 ... addressed the scientific basis of PDT and its benefits in clinical practice across ...
(Date:12/5/2018)... (PRWEB) , ... December 04, 2018 , ... ... sciences and diagnostics companies, announces the placement of Michael Mercer at Karius, Inc. ... business strategy, Mr. Mercer will be based at Karius' headquarters in Redwood City, ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... December 12, 2018 , ... RURO, Inc., a leading provider ... ML (Machine Learning) addition for its Limfinity® 7 framework. , Limfinity® ML ... the module, trained models make predictions based on user inputs; the result of ...
(Date:12/5/2018)... ... December 05, 2018 , ... Leading authority on how ... how-to guide with his “The Referral Playbook: How to Increase Sales with Proven ... book proceeds will go to the Alzheimer’s Foundation of America (AFA). , Itzkowich ...
(Date:11/29/2018)... ... ... RAGS, today announced the closing of a $1.5 million Second Seed round investment. ... board member Jeremy Andrus, CEO of Traeger Grills, as well as James Ho of ... to accelerate its growth and expand the product line. RAGS has now raised a ...
(Date:11/20/2018)... ... November 19, 2018 , ... ... the release of the Chinese translation of Best Practices: Recommendations for Repositories, Fourth ... practice-changing publication aimed at advancing the science of biobanking to meet the needs ...
Breaking Biology Technology:
Cached News: