In the April 5 issue of Circulation: Journal of the American Heart Association, researchers demonstrated for the first time that administration of clinically relevant doses of Viagra, generically known as sildenafil citrate, one-hour prior to the administration of the anti-cancer drug doxorubicin (DOX) prevented heart damage at the cellular level. The research also showed that the impotence drug also prevented dilated cardiomyopathy and heart failure in a chronic mouse model. Furthermore, researchers observed a reduction of DOX-induced cell death, an improvement of heart function, and a reduction of electrophysiological abnormalities associated with heart sickness.

"Our research holds promise for the potential use of sildenafil in patients receiving DOX as part of their chemotherapeutic regimen with the goal of reducing the incidence of DOX cardiomyopathy," said the lead author of the study, Rakesh C. Kukreja, Ph.D., professor of medicine, physiology and biochemistry at VCU.

"Viagra stabilizes the mitochondria and protects against free-radical damage of the mitochondria and heart dysfunction caused by treatment with DOX by opening the mitochondrial KATP channels in cardiac cells," said Kukreja.

Mitochondria are cellular organelles critical for converting oxygen into ATP, the key fuel for cellular function. According to Kukreja, free radicals generated in the mitochondria of cardiac cells by DOX lead to the break down of regular cellular function, resulting in programmed cardiac cell death. Over time, cell death has been linked to decreased heart function or heart failure.

DOX is an effective chemotherapeutic agent commonly used in the treatment of many bloo
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Contact: Anne Buckley
albuckley@vcu.edu
804-828-6052
Virginia Commonwealth University
5-Apr-2005