Vaccine hope for sufferers of potentially fatal stomach bug

Scientists at The University of Nottingham have been awarded over 366,000 to help unravel the mystery of a stomach bug which causes gastric ulcers and cancer. Their research could lead to the development of a vaccine for those most at risk.

The bacterium, Helicobacter pylori (Hp), lives in the stomachs of approximately half the worlds population. Dr Karen Robinson, a lecturer at the Centre of Biomolecular Sciences and co-researcher John Atherton, Professor of Gastroenterology and Head of the Wolfson Digestive Diseases Centre, lead a team of scientists that have spent the last three years trying to discover why most people are immune to the bug while it can cause potentially fatal disease in some people.

Dr Robinson says this new funding, from the Medical Research Council, will allow them to address one of the most important questions in Helicobacter research why some infected individuals develop ulcers or gastric cancer whilst others remain asymptomatic. My interest is in the immune response and how this dictates whether or not an infected person goes on to develop disease.

In recent studies the team has shown that the bacteria induce changes to the immune system which calm the inflammation down. However, sometimes this relationship goes wrong. Their experiments showed that people with ulcers often have a suppressed protective response, leading to the development of severe inflammation and ulceration of the stomach lining.

If we become infected with Hp it generally happens in childhood. The bacteria can remain undetected in the stomach for life. However, in some people it causes inflammation which leads to gastric ulcers or cancer in later years. Scientists at The University of Nottingham believe the Hp manipulates the immune system and patients arent aware of a problem until the disease has become so advanced they need surgery or chemotherapy.

The occurrence of the disease is currently thought to be due to

Contact: Karen Robinson
University of Nottingham

Page: 1 2

Related biology news :

1. Vaccine trials inject hope into koalas future
2. Vaccine hope for malaria
3. Vaccine prevents prion disease in mice
4. Vaccine to cope with viral diversity in HIV
5. PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. Vaccine-producing plant-factories
8. HPV Vaccine: Whats next
9. Vaccine shown effective against chancroid
10. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
11. Vaccine provides 100 percent protection against avian flu virus in animal study

Post Your Comments:

(Date:10/26/2015)... and LAS VEGAS , Oct. ... Labs , an innovator in modern authentication and a ... announced the launch of its latest version of the ... enabling organizations to use standards-based authentication that supports existing ... S3 Authentication Suite is ideal for organizations deploying customer-facing ...
(Date:10/23/2015)... Research and Markets ( http://www.researchandmarkets.com/research/zl6bz4/global_voice ) has ... Biometrics Market 2015-2019" report to their offering. ... global voice recognition biometrics market to grow at a ... --> --> The report, Global Voice ... an in-depth market analysis with inputs from industry experts. ...
(Date:10/22/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier of biometrics ... ended September 30, 2015.  --> ... million, a decrease of 33% compared to $6.0 million in the ... 2015 was $2.2 million, or $0.10 per diluted share, which compared ... period a year ago.  --> ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015 Cepheid (NASDAQ: CPHD ) ... the following conference, and invited investors to participate via ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern ... New York, NY      Tuesday, December 1, ...
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: ... behalf of the Toronto Stock Exchange, confirms that as ... no corporate developments that would cause the recent movements ... --> About Aeterna Zentaris Inc. ... --> Aeterna Zentaris is a specialty biopharmaceutical company ...
(Date:11/24/2015)... SHPG ) announced today that Jeff Poulton , ... Annual Healthcare Conference in New York City ... (1:30 p.m. GMT). --> SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> Shire ...
(Date:11/24/2015)... ... November 24, 2015 , ... In ... paramount. Insertion points for in-line sensors can represent a weak spot where leaking ... 781/784 series of retractable sensor housings , which are designed to tolerate extreme ...
Breaking Biology Technology:
Cached News: