HOME >> BIOLOGY >> NEWS
Vaccine prevents prion disease in mice

BOSTON An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 May 5, 2007. Prion diseases, which include scrapie, mad cow disease, and chronic wasting disease, are fatal and there is no treatment or cure.

The disease spreads when an animal eats the body parts of other animals contaminated with prions. The disease causes dementia and abnormal limb movements.

Prion is a protein that is also an infectious agent. The proteins are so similar to proteins found normally that the immune system does not fight them off. To develop a vaccine that would stimulate the mice's immune system, researchers attached prion proteins to a genetically modified strain of Salmonella.

For the study, the mice were orally vaccinated with a safe, attenuated Salmonella strain, which expressed the prion protein. Then they were divided into two groups those who had high levels of antibodies in their blood and thus responded well to the vaccine and those with low levels of antibodies.

The mice with high levels of antibodies had no symptoms of the disease after 400 days. The mice with low levels of antibodies also had a significant delay in the onset of the disease. It normally takes 120 days for mice that have not been vaccinated to develop the disease.

"These are promising findings," said study author Thomas Wisniewski, MD, of NYU School of Medicine in New York, and a member of the American Academy of Neurology. "We are now in the process of redesigning the vaccine so it can be used on deer and cattle."

Wisniewski said much more work is needed before the vaccine could be considered for humans. "The human version of prion disease usually occurs spontaneously and only rarely because of eating contaminated meat," he said. "But if, for example, a more significant outbreak
'"/>

Contact: Angela Babb
ababb@aan.com
651-695-2789
American Academy of Neurology
3-May-2007


Page: 1 2

Related biology news :

1. Vaccine trials inject hope into koalas future
2. Vaccine hope for malaria
3. Vaccine hope for sufferers of potentially fatal stomach bug
4. Vaccine to cope with viral diversity in HIV
5. PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. Vaccine-producing plant-factories
8. HPV Vaccine: Whats next
9. Vaccine shown effective against chancroid
10. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
11. Vaccine provides 100 percent protection against avian flu virus in animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... (PRWEB) , ... March 08, 2019 , ... ... (SITC) is pleased to announce a new initiative focused on women in the ... one-and-a-half day, free program that seeks to celebrate and empower emerging female leaders ...
(Date:3/9/2019)... PRINCETON, N.J. (PRWEB) , ... March 09, 2019 ... ... and highly potent hM3Dq & hM4Di ligands – exciting compounds for scientists studying ... National Institute on Drug Abuse and the National Institute of Neurological Disorders and ...
(Date:3/1/2019)... ... 2019 , ... Geneious would like to announce it is extending the reach ... , Geneious Prime already has a dedicated importer for Vector NTI Advance databases ... will be organised in Geneious in the same way. The next update (expected ...
Breaking Biology News(10 mins):
(Date:3/18/2019)... ... March 18, 2019 , ... For more than 15 years, USDM ... allow life science companies to easily comply with FDA 21 CFR Part 11 and ... a managed service delivering end-to-end GxP compliance from vendor audit through ongoing validation maintenance, ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... announcing that its Canadian partner, the Eye Machine Canada Inc., had been given ... pioneering technology for treating Age-Related Macular Degeneration (AMD). , The previous month, the ...
(Date:3/12/2019)... DENVILLE, N.J. and LIÈGE, Belgium (PRWEB) , ... ... ... for complete solutions for sample preparation and epigenetics research, has launched its third ... the features of the second generation instrument with a user-friendly interface, automated ...
(Date:3/5/2019)... ... March 05, 2019 , ... San Fransisko, or Sisko for ... him at four years old to pursue a career in dressage. According to ... most talented horse that she’d ever worked with. Unfortunately, Sisko suffered an injury ...
Breaking Biology Technology:
Cached News: