HOME >> BIOLOGY >> NEWS
Vaccine shown effective against chancroid

CHAPEL HILL HIV plagues more than 25 million people in sub-Saharan Africa, according to the World Health Organization, and efforts to develop a vaccine against the virus have achieved limited success.

But what if a vaccine against another sexually transmitted infection found widely in that region of Africa chancroid was relatively easy to develop and could reduce transmission of HIV as much as 10-fold?

That may be the case, according to researchers from the University of North Carolina at Chapel Hill's School of Medicine and N.C. State University's College of Veterinary Medicine.

Their study appears in the April issue of the journal Infection and Immunity. The lead author is Dr. Galyna Afonina, postdoctoral research associate in the UNC Center for Infectious Diseases. Senior author is Dr. Christopher Elkins, research associate professor in the departments of medicine and microbiology and immunology in UNC's School of Medicine.

Chancroid, a sexually transmitted disease that causes genital ulcers, is rare in the United States but takes hold in communities that have little or no access to health care, such as in Africa. Recent studies show that genital ulcer diseases such as chancroid can enhance HIV transmission three- to 10-fold.

"There is considerable evidence that genital ulcers are independent risk factors for the transmission of HIV, and chancroid may be the most important one," said Elkins.

Chancroid is caused by a bacterium, Haemophilus ducreyi, that normally infects only humans. Unlike most bacteria, Haemophilus species are unable to synthesize heme, the ferrous, or iron-containing, component of hemoglobin, and obtain it from host hemoglobin.

The researchers found that immunizing swine with a purified hemoglobin receptor protected the animals from a challenge infection, even after multiple attempts at infection.

Blood tests showed that the immunized pigs formed antibodies that prevented the chancroid bacteria from
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
5-May-2006


Page: 1 2 3

Related biology news :

1. Vaccine trials inject hope into koalas future
2. Vaccine hope for malaria
3. Vaccine prevents prion disease in mice
4. Vaccine hope for sufferers of potentially fatal stomach bug
5. Vaccine to cope with viral diversity in HIV
6. PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
7. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
8. Vaccine-producing plant-factories
9. HPV Vaccine: Whats next
10. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
11. Vaccine provides 100 percent protection against avian flu virus in animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... July 30, 2020 ... ... Therapeutics’ maturing prescription digital therapeutics product portfolio with a near term focus on ... diverse biotech and pharma commercialization experience across multiple therapeutic areas and classes. As ...
(Date:7/10/2020)... ... 08, 2020 , ... Overcoming Comparability Issues in Regenerative Medicines ... Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy , ... way to complete one? Will the study comply with all FDA requirements? Understanding ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... , ... “We are thrilled to deliver this new technology to the industry” ... kind on the market and we were pleased that the IFT jury recognized that.” ... ingredients, creating a natural way to extend the shelf life and improve the safety ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra ... life sciences and food industries, is pleased to announce that Charles Galea has ... Business Development. , Charles is an accomplished and results-driven sales executive with over ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... announced today that Massachusetts Institute of Technology (MIT) has expanded the company’s ... allows PathSensors to move into the point-of-care diagnostic market, focusing initially on ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, ... the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. ... of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor ...
Breaking Biology Technology:
Cached News: