HOME >> BIOLOGY >> NEWS
Vaccine to cope with viral diversity in HIV

The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine. David Nickle et al present here an efficient algorithm to develop vaccines that cope with the diversity of HIV or other variable pathogens.

This computational method clarifies and analyzes the variation found in the strains of the virus by describing the molecules which stimulate the immune response to HIV (immunogens) that have multiple forms of variable elements of the virus. These antigens compress the variation found in many viral strains into lengths suitable for vaccine immunogens. "We can capture 62% of the variation found in the Nef protein and 81% of the variation in the Gag protein into immunogens of three gene lengths", says Nickle.

These short-length immunogens are potentially useable in a vaccine, as they reflect the diversity of features in HIV-1 strains. These immunogens should elicit immune responses against high frequency viral strains as well as against most mutant forms of the virus.


'"/>

Contact: James Mullins
jmullins@u.washington.edu
206-732-6163
Public Library of Science
26-Apr-2007


Page: 1

Related biology news :

1. Vaccine trials inject hope into koalas future
2. Vaccine hope for malaria
3. Vaccine prevents prion disease in mice
4. Vaccine hope for sufferers of potentially fatal stomach bug
5. PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. Vaccine-producing plant-factories
8. HPV Vaccine: Whats next
9. Vaccine shown effective against chancroid
10. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
11. Vaccine provides 100 percent protection against avian flu virus in animal study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Vaccine cope with viral diversity HIV

(Date:8/27/2014)... mastodons, short-faced bears, giant ground sloths, saber-toothed cats ... 13,000 years ago at the end of the Pleistocene ... been debated by scientists who, until recently, could only ... including UC Santa Barbara,s James Kennett, professor emeritus in ... collision with Earth played a major role in the ...
(Date:8/27/2014)... began exploring land and evolved into tetrapods today,s amphibians, ... used their fishy bodies and fins in a terrestrial environment ... , Researchers at McGill University published in the journal ... Polypterus , to help show what might have happened when ... Polypterus is an African fish that can breathe air, ...
(Date:8/27/2014)... An invasive grass species frequently found in forests ... then feed on American toads, a new University of ... accidentally introduced to the U.S. in the early 1900s, ... has spread to more than a dozen states in ... along roads and in forests, it can survive in ...
Breaking Biology News(10 mins):Nanodiamonds are forever 2Nanodiamonds are forever 3Walking fish reveal how our ancestors evolved onto land 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
(Date:8/27/2014)... , Aug. 27, 2014   MSC , ... patient safety, today announced the appointment of Mary ... With 28 years of experience preparing companies for ... 2013 as Executive Vice President of Corporate Development and ... performance improvement business , as well as corporate strategy ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... of the "Global Lactic Acid  (Biodegradable Polymer, ... - Trends & Forecasts to 2019" report ... the simplest hydroxyl-carboxylic acid with an asymmetrical carbon ... in the biodegradable polymer, food and beverage, personal ...
(Date:8/27/2014)... -- Guggenheim Securities, the investment banking and capital markets ... veteran equity analyst Charles "Tony" Butler as a managing ... on the biotech/biopharma sector. " Tony Butler ... a broad network of relationships in his industry," said ... of Equities at Guggenheim Securities. "His insights will further ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 ... state of the global isotope ratio mass spectrometer industry. ... the industry including definitions, classifications, applications and industry chain ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
Cached News: