HOME >> BIOLOGY >> NEWS
Vaccine to cope with viral diversity in HIV

The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine. David Nickle et al present here an efficient algorithm to develop vaccines that cope with the diversity of HIV or other variable pathogens.

This computational method clarifies and analyzes the variation found in the strains of the virus by describing the molecules which stimulate the immune response to HIV (immunogens) that have multiple forms of variable elements of the virus. These antigens compress the variation found in many viral strains into lengths suitable for vaccine immunogens. "We can capture 62% of the variation found in the Nef protein and 81% of the variation in the Gag protein into immunogens of three gene lengths", says Nickle.

These short-length immunogens are potentially useable in a vaccine, as they reflect the diversity of features in HIV-1 strains. These immunogens should elicit immune responses against high frequency viral strains as well as against most mutant forms of the virus.


'"/>

Contact: James Mullins
jmullins@u.washington.edu
206-732-6163
Public Library of Science
26-Apr-2007


Page: 1

Related biology news :

1. Vaccine trials inject hope into koalas future
2. Vaccine hope for malaria
3. Vaccine prevents prion disease in mice
4. Vaccine hope for sufferers of potentially fatal stomach bug
5. PATH Malaria Vaccine Initiative announces partnership to develop novel malaria vaccine
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. Vaccine-producing plant-factories
8. HPV Vaccine: Whats next
9. Vaccine shown effective against chancroid
10. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
11. Vaccine provides 100 percent protection against avian flu virus in animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2019)... ... May 13, 2019 , ... NRD, LLC is excited ... on May 15-16, 2019, the largest medical technology event in the Northeast serving ... embedded systems product organizations. , They will be displaying their latest technologies, including ...
(Date:5/8/2019)... ... May 08, 2019 , ... RG+A, Inc., ... Carol S. Mann has agreed to serve as Chief Executive Officer and pharmaceutical ... Officer, effective immediately. They will join Chairman and Founder Roger Green to create ...
(Date:5/8/2019)... ... May 08, 2019 , ... ... diameter of 200 microns and a lead-in fiber of 100 microns. With dimensions ... standard and positioning itself as the world leader in the development of fiber ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... The American Society of ... the Society's leadership team, including a new addition to the presidential line of succession, ... peers to join the Society's leadership team for a three-year term (2019-2021). , All ...
(Date:4/8/2019)... New Zealand (PRWEB) , ... April 09, 2019 ... ... emerging infectious disease, the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) ... The study of antibody repertoires is part of CZ Biohub’s efforts to establish ...
(Date:3/29/2019)... ... March 28, 2019 , ... ... milestones, CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ ... which is on top of the $1.7 million already awarded by CARB-X. The ...
(Date:3/27/2019)... ... 27, 2019 , ... Lachman is sponsoring the event on April 1-4, where ... Ireland. The executive team on site will be available to discuss strategies and tactics ... agenda this year. , Executives from Lachman participating at this year’s conference include Fran ...
Breaking Biology Technology:
Cached News: