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Variation in bitter-taste receptor gene increases risk for alcoholism

that individuals with this variant also tend to be less sensitive to bitter tastes as suggested by the cell culture experiments.

As part of this investigation, Goate's team took advantage of available genome sequence databases to speed work in identifying and studying genes on chromosome 7. She says data from the Human Genome Project allowed the investigators to more quickly recognize individual variations in genes, called polymorphisms, that can influence how a gene product or protein functions.

As part of this study, Goate's team sequenced the TAS2R16 receptor gene in a number of individuals, but they didn't identify genetic variants they hadn't found already in the public databases.

The variant that increases risk of alcohol dependence was common in African Americans -- where about 45 percent of those studied carried this variation in the TAS2R16 receptor gene -- but rare in Caucasians -- where only 0.6 percent had this variation. Although the increased incidence of the variant means a larger percentage of African Americans are at risk because of this genetic factor, the variant in the TAS2R16 receptor also significantly increased risk in those Caucasians who carried the genetic variation.

The fact that this particular genetic variation is more common in African Americans does not necessarily mean African Americans will have a higher incidence of alcoholism. The difference in the TAS2R16 gene is only one of several genetic and environmental factors involved in risk for alcoholism, according to Goate.

"I don't think our result has any implications for the levels of alcoholism within different populations," Goate says. "We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk."


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Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
9-Jan-2006


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