HOME >> BIOLOGY >> NEWS
Variation in women's X chromosomes may explain differences among individuals, between sexes

Durham, N.C. The first comprehensive survey of gene activity in the X chromosomes of women has revealed an unexpected level of variation among individuals, according to new work by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and Pennsylvania State University.

The results may have important implications for understanding the differences in traits among women and between males and females, in terms of both health and disease, said Huntington Willard, Ph.D., director of the IGSP and the study's senior author. The findings also offer new insight into the basis for well-established differences between the sexes, he said.

Willard said that the extensive variation in gene activity in the sex chromosomes means that, in essence, there is not one human genome, but two -- male and female.

"We looked at the X chromosomes of 40 women and every one of them had a unique pattern of gene expression," Willard said. "All of that variation is completely unique to women. The X chromosomes of males are all the same in this regard."

Willard and study co-author Laura Carrel, Ph.D., of Penn State, reported their findings in the March 17, 2005, issue of Nature. The National Institutes of Health supported the research. In the same issue of Nature, more than 250 researchers including Willard and Carrel, reported the complete DNA sequence of the human X chromosome.

In animals, sexual identity is governed by sex chromosomes. In humans and other mammals, males have one X and one Y chromosome, while females have a pair of X's.

Many genes on the male Y chromosomes have been lost over evolutionary time, leaving the chromosome with fewer than 100 functional genes. In contrast, the X chromosome -- present in at least one copy in both sexes -- encodes more than 1,000.

More than 45 years ago, researchers discovered that genes on one copy of the female's X chromosome are switched off, a modification known as X
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-660-1306
Duke University Medical Center
16-Mar-2005


Page: 1 2 3

Related biology news :

1. Variation in 3 genes influences risk of age-related macular degeneration
2. Variation in CHEK2 gene may triple breast cancer risk
3. Variation in bitter-taste receptor gene increases risk for alcoholism
4. Variation in HIVs ability to disable host defenses contributes to rapid evolution
5. Variation in immune response gene causes age-related macular degeneration when triggered
6. Risk-taking in infertility treatment correlates with womens negative moods
7. Physicist cracks womens random but always lucky choice of X chromosome
8. Male sweat boosts womens hormone levels
9. Heavy smoking cuts womens chance of pregnancy -- even with donated oocytes
10. New survey reveals womens attitudes about feminine health
11. First high-tech incubator at a womens college says girls can do science

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: