HOME >> BIOLOGY >> NEWS
Vax and Pax: Taking turns to build an eye

Opposing ball clubs don't take the field at the same time, and neither do teams of proteins responsible for creating the eye. While one team builds the retina, in adjacent cellular turf the opponents are busy constructing the cord that carries visual signals to the brain. And these guys aren't supposed to mingle.

That's why researchers at the Salk Institute for Biological Studies were surprised to find the respective team captains--Vax2, a protein that along with Vax1 builds the optic nerve cord, and Pax6, a protein that drives retinal fate--playing on the same field. That puzzle is explained in a forthcoming paper in Genes and Development.

Earlier studies from the laboratory of Greg Lemke, Ph.D., professor in Salk's Molecular Neurobiology Laboratory, had shown that Vax2 antagonized Pax6. "We knew that Vax1 and 2 acted together to inactivate Pax6. That's how you get an optic nerve--by preventing it from becoming a retina," explains Lemke. The only problem was that later on both Vax2 and Pax6 were co-expressed in the same cells. "If Vax2 was repressing Pax6 this seemed inconsistent," he says.

Both proteins bind DNA and function in a cell's nucleus to switch genes on and off. Pax6 regulates the development of the retina, while Vax2 ensures that the optic nerve gets built. Finding both proteins in the same nucleus would make about as much sense as having runners for the Giants and the Dodgers on base at the same time.

Analyzing eye development in both mouse and chick tissues, Lemke and former postdoctoral fellow Jin Woo Kim, Ph.D., solved the mystery. Stina Mui, a former graduate student in the Lemke lab had originally observed Vax2 in the cytoplasm of cultured cell lines and Kim had taken on the task of figuring out why. He showed that Vax2 protein is indeed expressed in the same retinal cells as Pax6, but that Vax2 shuttles in and out of the nucleus in response to a signaling molecule known as Sonic hedgehog.

"Va
'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
14-Oct-2006


Page: 1 2 3

Related biology news :

1. Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
2. Taking heart failure to the MAT1
3. Taking chips to the next level of gene hunting
4. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
5. Taking a bite out of a fellow worker helps wasps recruit new foragers
6. Taking a break from fractures: A closer look at vitamin D
7. Taking a flying jump
8. Taking the piste out of Alpine vegetation
9. Taking the next step toward growing our own fuel
10. OHSU turns mouse into factory for human liver cells
11. Leukemia drug turns mini-molecules up, cancer genes down

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2019)... ... ... Zolgensma (Novartis, AveXis), an AAV-delivered gene therapy used to treat spinal muscular ... States by the Food and Drug Administration today. , The treatment is ... the United States and the second-ever approved treatment for SMA. , FDA granted priority ...
(Date:5/23/2019)... ... May 23, 2019 , ... ... for sales and service organizations, today announced its inclusion in DMG Consulting’s ... as the intelligent virtual agent (IVA) market share leader, based on number of ...
(Date:5/21/2019)... ... ... Suvoda LLC , a SaaS provider of Interactive Response Technology (IRT) ... Inc. Magazine’s Best Workplaces for 2019, Inc.’s fourth annual ranking of the fast-growing private ... the newsstands on May 28, is the result of a comprehensive measurement of private ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... ... May 06, 2019 , ... ... the growing number of repositories being asked to store cellular products being ... team of contributors who are world leaders, who have shared their expertise in ...
(Date:5/2/2019)... , ... April 30, 2019 ... ... International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. has demonstrated ... requirements. In addition, REPROCELL USA Inc. aims to enhance customer satisfaction through ...
(Date:5/2/2019)... ... May 02, 2019 , ... Researchers from ... documenting discrepancies between U.S. insurer policies for genetic testing and the 2019 National ... breast and ovarian cancer (HBOC). , Jill S. Dolinsky, director of ...
(Date:4/25/2019)... ... April 24, 2019 , ... Inference Solutions , a ... today announced global availability of Inference Studio’s latest version, which makes it easier ... harness the power of Google’s Contact Center AI (CCAI). , As ...
Breaking Biology Technology:
Cached News: