HOME >> BIOLOGY >> NEWS
Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes

BETHESDA, Md. (June 29, 2005) Normally your kidneys filter about 50 gallons of blood a day, remove such waste as salts and minerals, and concentrate it into urine. When you exercise or don't take in water, your blood "thickens" and instead of removing water, the kidney reverses the process, pulls in water from the body that would normally go into the urine, and puts it into the blood, thus maintaining water balance.

Various diseases disrupt this process and in one small population the kidneys keep dumping watered-down urine into the bladder, at the rate of about 5 gallons a day compared with the normal quart or so. Besides the obvious inconvenience, people with nephrogenic diabetes insipidus (NDI) are constantly thirsty and in danger of severe dehydration, electrolyte imbalance, and have other problems that may ultimately require a kidney transplant.

Wanted: way to bypass defective vasopressin receptors

While the disease is rare, its cause is known, involving malfunctioning receptors (V2R) for the anti-diuretic hormone vasopressin. Based on their earlier work, researchers at Massachusetts General Hospital-Harvard Medical School, Boston, believed they might be able to bypass the V2R and alleviate NDI symptoms by activating the kidney's water channels, called aquaporins, through a different mechanism.

Their study, entitled "Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)," is in the June issue of the American Journal of Physiology-Renal Physiology, published by the American Physiological Society. The research was conducted by Richard Bouley, Nuria Pastor-Soler, Ori Cohen, Margaret McLaughlin, Sylvie Breton and Dennis Brown at Massachusetts General Hospital (MGH) and Harvard Medical School, Boston.

Dennis Brown, director of the Program in Membrane Biology in the MGH Renal Unit, said "it's a target-trafficking proble
'"/>


29-Jun-2005


Page: 1 2 3

Related biology news :

1. Viagra improves high altitude exercise performance up to 45% for some
2. Viagras hidden help for wildlife
3. Viagra interferes with plant sexual reproduction
4. VCU research shows Viagra prevents anti-cancer drug induced heart damage
5. Viagra shows selective effects in hypertensive pregnancy on mother, fetus
6. Clones on task serve greater good, evolutionary study shows
7. Research shows skeleton to be endocrine organ
8. An early ape shows its hand
9. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
10. Huntingtons disease study shows animal models on target
11. Research shows NPD1 protects a key component of vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... SOMERSET, N.J. (PRWEB) , ... August 25, 2020 ... ... technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and ... the upcoming 16th Annual PEGS Boston Virtual Conference & Expo, taking place between ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., a ... U.S. Food and Drug Administration (FDA) has approved the company’s Investigational New Drug ... of severe COVID-19. Approval of this IND allows Sentien to initiate a Phase ...
(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a leading ... despite many obstacles created as a result of COVID-19. As a provider at ... medical practices and medical manufacturers by expanding access to device offerings, technology services, ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... today announced the company has entered a license agreement with Roswell Park Comprehensive ... globally exclusive rights to Roswell Park intellectual property surrounding a novel medical device ...
Breaking Biology Technology:
Cached News: