HOME >> BIOLOGY >> NEWS
Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes

ater channel." (Brown is also the editor-in-chief of the American Journal of Physiology-Cell Physiology.)

Caveats, next steps and implications for other diseases

However, Brown warned that aquaporin accumulation is "only one step in the cascade, and we have shown that a clinically approved drug has a useful effect. However, now we need to understand the physiology of the whole kidney." Other "next steps" include:

  • Since the enzyme inhibited by Viagra is in vascular cells as well as in kidney cells, administration of Viagra also increases blood flow, putting extra pressure on kidneys.

  • Recent evidence indicates that PDE5 inhibition is associated with excretion of abnormal amounts of sodium in the urine.

  • Because the present study was performed over a short time period, only a small effect on final urine concentration was found. Long-term studies need to now be carried out, and combination therapy as well as maintenance of subjects on a low-sodium diet need to be tested.

  • The paper adds: "metabolism of sildenafil citrate between human and rat is different."

Although statistics are hard to come by, fewer than 700 Americans, mostly male, have inherited forms of NDI. Many more patients have acquired NDI through using certain prescription drugs, or other physical conditions or diseases, but the total is still small.

"Studying the vasopressin receptor's mutations that affect urine concentration was a chance to understand the role of some amino acids or sequence motifs on this protein in cell physiology," lead author Bouley said. "This knowledge may be applied to other proteins and other diseases involving protein trafficking, including cystic fibrosis, where abnormal proteins trapped in cells can't perform their normal physiological function," Bouley noted.


'"/>


29-Jun-2005


Page: 1 2 3

Related biology news :

1. Viagra improves high altitude exercise performance up to 45% for some
2. Viagras hidden help for wildlife
3. Viagra interferes with plant sexual reproduction
4. VCU research shows Viagra prevents anti-cancer drug induced heart damage
5. Viagra shows selective effects in hypertensive pregnancy on mother, fetus
6. Clones on task serve greater good, evolutionary study shows
7. Research shows skeleton to be endocrine organ
8. An early ape shows its hand
9. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
10. Huntingtons disease study shows animal models on target
11. Research shows NPD1 protects a key component of vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: