HOME >> BIOLOGY >> NEWS
Virus widely used in gene therapy research yields important clues to genomic instability

SEATTLE, May 31 Genomic instabilitythe rearrangement of chromosomes or an abnormal number of chromosomesis a hallmark of many human cancers. Although the source of genomic instability has been established for many inherited human cancers, the processes and genes involved in cancers that that are not inherited but arise sporadically remain largely unknown. Now, researchers at the University of Pittsburgh School of Medicine say they have the ability to study the potential cause of genomic instability in sporadic cancers using a recombinant adeno-associated virus, the same virus that many researchers around the world use for gene therapy experiments. The results of their work are being presented at the 10th annual meeting of the American Society of Gene Therapy, which is being held May 30 to June 3 at the Washington State Convention & Trade Center, Seattle.

Recombinant adeno-associated virus (rAAV) is a powerful vehicle to deliver genes into various tissues in cells and animals, and these viruses, or vectors, are of great interest not only in the field of human gene therapy but also as a tool to express genes of interest in target cells for research on various human diseases. It is now possible to express a gene of interest in 100 percent of target cells in organs in mice, including liver, skeletal muscle and heart, by a single injection of a rAAV vector into a peripheral vein.

Recent research has demonstrated that rAAV can only insert itself into host chromosomes at sites that are prone to DNA breaks. The research team, led by Hiroyuki Nakai, M.D., Ph.D., assistant professor of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, recently established a novel method to isolate rAAV integration sites in non-dividing cells on a large scale. They have used this method to identify approximately 1,000 integration sites in mouse liver, skeletal muscle and heart. Furthermore, of 945 rAAV integration sites mapped to the mous
'"/>

Contact: Jim Swyers
SywersJP@upmc.edu
412-657-4957
University of Pittsburgh Schools of the Health Sciences
31-May-2007


Page: 1 2

Related biology news :

1. The sweet science: Viruses switch grip to gain upper hand
2. Virus may control Australias "river rabbit"
3. Viruses can jump between primates and humans, researchers warn
4. Virus has catastrophic affect on red squirrels, research shows
5. Smooth sailing: Cruise Ship Virus tackled by UH, Baylor College of Medicine
6. Virus linked to Thoroughbred abortion epidemic
7. New strategy developed to combat West Nile Virus
8. Virus chip detects new virus in prostate tumors
9. Secrets to antibodys success against West Nile Virus surprise scientists
10. Virus uses tiny RNA to evade the immune system
11. Virus-host interactions at sea effect global photosynthesis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... for salient features of seizure risk signals, usually based on variations of amplitude, ... remains the only acceptable diagnostic methodology due to the complexity and variability of ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, ... and mobile, announces the launch of version 13.1. The new version extends FileWave’s ... API, and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s version ...
(Date:5/31/2019)... ... May 31, 2019 , ... ... Westchase in Houston, TX, announced today that Ben Reiter, Senior Writer at Sports ... of Wednesday, October 3rd.     , Reiter predicted the Houston Astros would win the ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... ... to demonstrate an efficient delivery system for the sustained release of human placental ... plasma-based gel system was able to deliver CM into the injured kidney, where ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates (LDA), the ... Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce the go-live ... LDA’s ability to communicate directly with the marketplace; serving as a destination to ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
(Date:5/2/2019)... ... May 02, 2019 , ... Boston ... greater Boston area. Gone are the days of painful hair transplant procedures. Boston ... Restoration System is the only robotic intelligent solution to offer a minimally invasive ...
Breaking Biology Technology:
Cached News: