HOME >> BIOLOGY >> NEWS
Vitamin extends life in yeast, Dartmouth Medical School researchers find

Hanover, NH--Imagine taking a vitamin for longevity! Not yet, but a Dartmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step closer.

The research, reported in the May 4 issue of Cell, shows how a new vitamin extends lifespan in yeast cells, much like calorie restriction does in animals. It could pave the way for developing supplements to benefit humans.

Radical calorie reduction can extend life. Dieting or fasting mice live longer and lowering the glucose that yeast grow on extends their lifespan, according to Dr. Charles Brenner, associate professor of genetics and of biochemistry, who led the research.

If we could do this in humans -- give people a drug or vitamin that would mimic effects of calorie restriction without having to skip lunch -- we would be able to provide some of the benefits of calorie restriction, which are pretty striking in model organisms, said Brenner, also a member of the Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center.

Many benefits, explains Brenner, depend on a family of proteins called sirtuinsdubbed anti-aging gene products for the important roles they play in longevity and energy expenditure, although the precise mechanisms are still being figured out.

His team found that providing a newly discovered vitamin activates the yeast anti-aging gene product Sir2, which resembles sirtuins found in humans. The new work builds on Brenners prior discovery of the vitamin, termed NR (nicotinamide riboside), a natural product found in milk. Like the B3 vitamin, niacin, NR is a precursor to a versatile cellular factor that is vital for all life.

The factor, called NAD, short for nicotinamide adenine dinucleotide, is elevated by calorie restriction. So the researchers set out to develop an intervention to elevate NAD, using yeast cells, whose genes are easy to manipulate. Its surprising that no one was be
'"/>

Contact: Hali Wickner
hali.wickner@dartmouth.edu
Dartmouth Medical School
3-May-2007


Page: 1 2 3

Related biology news :

1. Vitamin D, variations in its receptor and prostate cancer
2. Vitamin D deficiency widespread during pregnancy
3. Vitamin D3 provides the skin with protection from harmful microbes
4. Vitamin C and water not just healthy for people -- healthy for plastics, too
5. Vitamin D may cut pancreatic cancer risk by nearly half
6. Vitamin D and flavonoids examined for impact on breast and ovarian cancers
7. Nutritional friend or foe? Vitamin E sends mixed messages
8. Vitamin A analog is a potential lung cancer preventative with few side effects
9. Vitamin supplement could help treatment-resistant asthma
10. Vitamin As paradoxical role in influencing symmetry during embryonic development revealed
11. Vitamin E loss through smoking increases health risks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... building awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced ... Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and ...
(Date:6/25/2020)... ... 2020 , ... eClinical Solutions LLC , a leading ... drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) on randomized ... COVID-19. This is the first study of an XPO1 inhibitor in patients with ...
(Date:6/23/2020)... TORONTO (PRWEB) , ... June 22, 2020 , ... The ... time. Typically, ligand binding assays (LBA) have dominated this area. However, the use of ... several years. , This now necessitates the question “How do you choose which approach ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... highly reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, ... single controller that can drive one or two switches in a push-pull configuration; ...
(Date:7/31/2020)... ... 2020 , ... The SDX® Respiratory Gating System , ... reached its 20th anniversary of worldwide use. Introduced in the US over the ... University of Pennsylvania, University of Michigan, University of Maryland, University of California San ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new ... only technology of its kind on the market and we were pleased that the ... capacity of traditional cultured ingredients, creating a natural way to extend the shelf life ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... of Technology (MIT) has expanded the company’s exclusive license to include clinical ... the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ ...
Breaking Biology Technology:
Cached News: