David M. Sabatini, M.D., Ph.D., Whitehead Institute for Biomedical Research, Cambridge, MA
Dr. Sabatini investigates the metabolic adaptations that allow solid tumors to survive in a nutrient- and oxygen-poor environment and permit many cancers to evade treatment. He will also test how these adaptive mechanisms interact with genes that cause or suppress tumors. The research could lead to treatments to boost the effectiveness of other cancer therapies or prevent recurrences.
Kang Shen, M.D., Ph.D., Department of Biological Sciences, Stanford University, Stanford, CA
Dr. Shen studies how the nervous system forms at a molecular level during development. He plans to piece together the sequence of action by which dendrites are attracted to form synapses. This will be a necessary step in understanding degenerative neurological disorders, such as Parkinson's disease.
Chaired by William T. Butler, M.D., Chancellor Emeritus of Baylor College of Medicine, the Advisory Committee consists of: Norman Arnheim, Ph.D., Professor of Biological Sciences, Molecular Biology & Biochemistry, University of Southern California; Gerald R. Fink, Ph.D., Member, Whitehead Institute and Professor of Genetics, Massachusetts Institute of Technology; Elizabeth Neufeld, Ph.D., Professor of Biological Chemistry, University of California, Los Angeles; Robert R. Rich, M.D., Senior Vice President and Dean, School of Medicine, University of Alabama at Birmingham; and Marc Tessier-Lavigne, Ph.D., Senior Vice President, Research Drug Discovery, Genentech, Inc.