HOME >> BIOLOGY >> NEWS
Waging war on the deadliest superbug

It infiltrates hospitals as microscopic spores. Its defences are so strong it can resist most antibiotics. And it kills three times as many people every year as MRSA. But scientists at The University of Nottingham are amassing an arsenal of weapons in preparation for counter offensive against the most deadly of hospital superbugs.

A research group led by Professor Nigel Minton in the Centre for Healthcare Associated Infections (CHAI), with Dr Peter Mullany at University College, London have been awarded over 1.6m for one of the countrys largest studies into C.difficile (C. diff). The work funded by the Medical Research Council, follows a scientific breakthrough by CHAI microbiologists that is set to revolutionise the genetic analysis of Clostridium difficile and its close relatives.

Until now scientists have understood very little about the biology of C-diff. With funding from the Biotechnology and Biological Sciences Research Council (BBSRC) and Morvus Technology Ltd, Professor Nigel Minton and his team have developed the ClosTron knock out system which can target specific genes in C. diff and other clostridial species. For the very first time scientists have an extremely rapid and effective way of identifying and deactivating the toxins and other factors that cause the disease and can begin the search for new therapies to prevent or cure it.

Professor Minton said: Although we have the entire genetic blueprint of C.diff, and have an inkling as to what bacterial factors might be important in disease, we have been unable to test these ideas. You never really know what a particular factor is doing until it isnt there. You need to be able to inactivate, knock-out, the gene responsible, and then see if the bacterium can still cause disease. Until now knocking out genes has been very difficult to do. Our breakthrough ClosTron technology now makes gene knock-out very quick and easy. Once we know what factors are important we should
'"/>

Contact: Professor Richard James
44-011-584-67952
University of Nottingham
3-Jul-2007


Page: 1 2 3

Related biology news :

1. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
2. Bridge protein spurs deadliest stages of breast cancer
3. A fisheye view of the deadliest breast cancer
4. Einstein researchers find key to unlocking worlds deadliest malaria parasite
5. Researchers report breakthrough against worlds deadliest viruses
6. Key found to kill cystic fibrosis superbug
7. UBC researchers find new superbug weapon for near-empty antibiotics arsenal
8. New antibacterials being developed to tackle MRSA superbug
9. Unusual antibiotics show promise against deadly superbugs
10. Return of the Staphylococcus aureus superbug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Tunnell Consulting ... sessions at the ISPE Annual Meeting and Expo , to be held October ... The event’s theme is “Driving innovation to advance patient therapies.” , The ISPE Annual ...
(Date:8/16/2017)... ... August 16, 2017 , ... Today, 3Bar Biologics ... secured $2M in funding from an impressive group of investors, including Rev1 Ventures, ... Fund. With this investment, 3Bar is broadening availability of its groundbreaking offering that ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art technology which ... offers this platform to healthcare stakeholders (hospitals, foundations, biopharma companies etc.) ... collection vis a vis their members, under their own brand. Three ... offer. ... ...
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem cell research or ... for more than half a century. Despite their essential roles in human health ... known that molecular tags developed for this purpose also tag other, more abundant, non-stem ...
Breaking Biology Technology:
Cached News: