HOME >> BIOLOGY >> NEWS
Weill Cornell team identifies potential new cancer drug target

NEW YORK (June 20, 2007) -- Research led by scientists at Weill Cornell Medical College has uncovered two new potential points of vulnerability on a key cancer-promoting protein, called XIAP. Drugs that target either of these activities could help push cancer cells back into a more regular programmed cell death and thereby reduce or eliminate tumors.

These findings were published in the June 8 issue of Molecular Cell by Dr. Hao Wu, a professor in the Department of Biochemistry of Weill Cornell, and her team.

Experts know that cancers spread in two separate ways -- by the uncontrolled proliferation of cells, and by their refusal to undergo normal, healthy, programmed cell death, or "apoptosis."

In many cancers, dysfunction in a biochemical cascade called the NF-kappa B pathway causes tumor cells to sidestep apoptosis and become dangerously immortal.

"So, drug development aimed at short-circuiting NF-kappa B has become very hot in the past few years," Dr. Wu says.

Her team focused on a particular protein involved in the NF-kappa B pathway called the "X-linked inhibitor of apoptosis" (XIAP). Scientists had already discovered that XIAP thwarts the apoptotic impulse by putting the brakes on key enzymes called caspases. XIAP is also known to be highly active in cancer cells, but it is found in relatively low levels in healthy cells. How XIAP inhibits caspases is known, but how XIAP induces NF-kappa B activation is entirely unclear.

"We wondered if we could find out how XIAP induces the NF-kappa B pathway," explains lead researcher Dr. Miao Lu, a postdoctoral fellow of biochemistry at Weill Cornell.

In their experiments, the researchers used a variety of cutting-edge techniques, including X-ray crystallography, to track changes in the structure and activity of XIAP and the molecules it interacts with in cells.

"We discovered that XIAP interacts with the NF-kappa B cycle in two distinct wa
'"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
21-Jun-2007


Page: 1 2

Related biology news :

1. Weill Cornell pharmacologist receives prestigious NIH MERIT Award
2. Stem cell research at Weill Cornell, The Rockefeller University, and Sloan-Kettering
3. Weill Cornell team develops fast-acting anthrax vaccine
4. Cornell scientists link E. coli bacteria to Crohns disease
5. Methodist, University of Houston, Cornell combine biomedical imaging expertise
6. Cornell lab confirms deadly fish virus spreading to new species
7. NSF awards $3.3 million grant to Cornell to bolster the percentage of women faculty members
8. Cornell researchers find serious fish virus in Northeast for first time
9. Cornell finds natural selection in humans
10. Northeast Sun Grant Institute at Cornell spurs green revolution
11. Cornell graduate student named 2005 AIBS Emerging Public Policy Leader

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... March 05, 2020 , ... In ... . The AlphaSTEM Test™ is the first, and still only, available technology ... technologies that attempt to provide information about the number and quality of therapeutic ...
(Date:3/3/2020)... Calif. (PRWEB) , ... March 03, 2020 , ... Amplify ... levels with the dualX Expanding Interbody Fusion System. , The landmark case ... CA. After the case Dr. Najafi noted, “dualX has completely changed the game ...
(Date:3/2/2020)... ... March 02, 2020 , ... Rigaku Corporation ... on Analytical Chemistry and Applied Spectroscopy ( Pittcon 2020 ), being held March ... leading annual conference and exposition on laboratory science, attracting attendees from industry, academia ...
Breaking Biology News(10 mins):
(Date:4/1/2020)... ... March 31, 2020 , ... Bedoukian Research, ... of a Joint Development Agreement that builds on each company’s expertise in developing ... leader in the supply of high-quality insect pheromones as well as flavors and ...
(Date:3/27/2020)... ... ... iFirst Medical Technologies, Inc., a leader in handheld diagnostic devices, announced today ... a grave danger to public health here in the U.S. and around the globe," ... testing and on-the-spot results promise to slow the spread and save human lives." , ...
(Date:3/19/2020)... ... 2020 , ... Family counsellors, marriage/couples therapists, and those interested ... their perceptions of events. Imagine if a couple’s counsellor could see the impact ... the level of engagement of each individual in the therapeutic process, then tailor ...
(Date:3/12/2020)... ... March 12, 2020 , ... With the beginning of 2020, ... business investment in Europe by inaugurating a new scientific facility for academic and ... new Nanoscience Center Europe took place Tuesday, February 18, 2020, gathering customers, collaborators ...
Breaking Biology Technology:
Cached News: