HOME >> BIOLOGY >> NEWS
Weizmann Institute scientists develop a general 'control switch' for protein activity

Our bodies could not maintain their existence without thousands of proteins performing myriad vital tasks within cells. Since malfunctioning proteins can cause disease, the study of protein structure and function can lead to the development of drugs and treatments for numerous disorders. For example, the discovery of insulins role in diabetes paved the way for the development of a treatment based on insulin injections. Yet, despite enormous research efforts led by scientists worldwide, the cellular function of numerous proteins is still unknown. To reveal this function, scientists perform various genetic manipulations to increase or, conversely, decrease the production of a certain protein, but existing manipulations of this sort are complicated and do not fully meet the researchers needs.

Prof. Mordechai Moti Liscovitch and graduate student Oran Erster of the Weizmann Institutes Biological Regulation Department, together with Dr. Miri Eisenstein of Chemical Research Support, have recently developed a unique switch that can control the activity of any protein, raising it several-fold or stopping it almost completely. The method provides researchers with a simple and effective tool for exploring the function of unknown proteins, and in the future the new technique may find many additional uses.

The switch has a genetic component and a chemical component: Using genetic engineering, the scientists insert a short segment of amino acids into the amino acid sequence making up the protein. This segment is capable of binding strongly and selectively to a particular chemical drug, which affects the activity level of the engineered protein by increasing or reducing it. When the drug is no longer applied, or when it is removed from the system, the protein returns to its natural activity level.

As reported recently in the journal Nature Methods, the first stage of the method consists of preparing a set of genetically engineered proteins (called
'"/>

Contact: Jennifer Manning
jennifer@acwis.org
212-895-7952
American Committee for the Weizmann Institute of Science
19-Jun-2007


Page: 1 2 3

Related biology news :

1. Weizmann Institute scientists discover a control mechanism for metastasis
2. Weizmann scientists discover a new line of communication between nervous system cells
3. Weizmann Institute scientists discover a key player in embryonic muscle development
4. Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
5. Weizmann Women & Science Award presented to Dr. Mary-Claire King
6. Mary-Claire King to receive the 2006 Weizmann Women & Science Award
7. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
8. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
9. Weizmann Institute scientists discover how substitutions are made for injured genes
10. Weizmann Insitute scientists show how proteins beat the evolutionary stakes
11. Technology award presented to Weizmann Institute scientist

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... , ... CrucialTrak, a global designer and manufacturer of biometric access control systems, ... market and sell its complete line of biometric readers and access gates . ... solutions . , Brett Mason, CrucialTrak’s Director of Channel Sales for the Americas ...
(Date:5/28/2020)... ... May 28, 2020 , ... ... results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be ... will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... in background and medical screening, announces the launch of a testing service ... workforce safe. The new service is provided by ClearStar’s Medical Information Services ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... ... multiple open heart surgeries before becoming adults. The reason: there are ... address this critical unmet need, the Department of Defense has awarded Draper, Boston ...
(Date:5/15/2020)... ... May 15, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage ... Ganz as Executive Chairman. Mr. Ganz will continue to lead Sentien’s Board of ... work closely with CEO Brian Miller and Sentien’s management team. , Mr. ...
(Date:5/14/2020)... ... May 12, 2020 , ... NanoString ... bringing together thousands of industry leaders, clinicians, research scientists, medical professionals and academics ... Carl June, MD, Director of the Center for Cellular Immunotherapies at the Perelman ...
(Date:5/14/2020)... ... May 13, 2020 , ... ... phenotypic readouts, providing little or no information on the drug’s mechanism of action ... characterization of compounds by measuring the activity of molecular pathways. This information can ...
Breaking Biology Technology:
Cached News: