HOME >> BIOLOGY >> NEWS
Weizmann Institute scientists discover how substitutions are made for injured genes

If there were no bench for second-string players on a football team, who would substitute for tired or injured team members? A team of Weizmann Institute scientists has found that, if the team were made up of genes, they might pull athletes who can play a little football in a pinch from nearby basketball or rugby teams. Their findings were published in the March issue of Nature Genetics.

Dr. Yitzhak (Tzachi) Pilpel and graduate students Ran Kafri and Arren Bar-Even, of the Institute's Molecular Genetics Department, knew from previous studies that up to 80% of the genes in yeast, a common model for genetics research, have potential stand-ins in various spots around the genome. Though not identical to the original gene, they make a protein that is sufficiently similar to the one it produces to pass muster. Many scientists believed that both genetic substitutes and the main gene were expressed simultaneously so as to supply the organism with needed quantities of proteins. But Pilpel and his team showed that, in fact, when the original gene is up and running, the others are off playing at their own sports. Only when that gene is damaged or deleted, do the substitutes get called onto the "football field," where they play as they can.

They reached this conclusion after analyzing data from some 40 studies of yeast cells by different research teams around the world. Using bioinformatics techniques (advanced data processing of biological information) to identify patterns and trends in the enormous flux of data supplied by these studies and by the sequencing of the yeast genome, they proposed a "football coach" mechanism that knows when to call up the substitute players.

This "coach" is a feedback mechanism based on the raw materials genes use to make proteins. When a gene is working at full capacity, it will use up most of the raw material available to it, leaving little in its original state. But, if it's not making sufficient quantities of prote
'"/>

Contact: Alex Smith
asmith@jgordonassociates.com
212-367-3892
American Committee for the Weizmann Institute of Science
2-Mar-2005


Page: 1 2

Related biology news :

1. Weizmann Institute scientists discover a control mechanism for metastasis
2. Weizmann scientists discover a new line of communication between nervous system cells
3. Weizmann Institute scientists develop a general control switch for protein activity
4. Weizmann Institute scientists discover a key player in embryonic muscle development
5. Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
6. Weizmann Women & Science Award presented to Dr. Mary-Claire King
7. Mary-Claire King to receive the 2006 Weizmann Women & Science Award
8. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
9. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
10. Weizmann Insitute scientists show how proteins beat the evolutionary stakes
11. Technology award presented to Weizmann Institute scientist

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... , ... April 24, 2019 , ... ... announces today the award of U.S. patent 10,191,929, “Systems and Methods for SNP ... and more efficient to conduct a variety of advanced bioinformatic analyses, including SNP ...
(Date:4/18/2019)... and WALNUT CREEK, Calif. (PRWEB) , ... April ... ... management solution for the healthcare industry, today announced the launch of mSource® AI ... processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly optimizing purchased ...
(Date:4/16/2019)... ... April 16, 2019 , ... HealthLink International, experts ... its new medical device facility on Friday, April 12. Headquartered in the Netherlands, ... new facility includes 108,500 square feet and houses 32 employees enabling HealthLink to ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... ... of a $2 million bench plant expansion to increase production of methylene malonate ... the design and construction of Sirrus’ full-scale production facility, which is scheduled to ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
Breaking Biology Technology:
Cached News: