HOME >> BIOLOGY >> NEWS
What are little boys made of?

CHARLOTTESVILLE, Va., March 11, 2005 -- What makes a man behave like a man and a woman a woman? The answer may be partly in your genes. Researchers at the University of Virginia Health System have discovered a new twist on the role that estrogens play in the development of behavioral differences between males and females.

In laboratory tests on mice, the researchers found evidence that an estrogen receptor in the hypothalamus called ER regulates defeminization, a process by which males lose the ability to display female-type behavior in adulthood. Defeminization is believed by many experts to be the main neurological process that differentiates males and females before birth. The discovery is detailed in the March 10 edition of the Proceedings of the National Academies of Sciences found at: www.pnas.org.

"Our hypothesis is that neonatal males are exposed to the steroid estradiol (a form of natural estrogen) produced by their testes. Estradiol binds to the estrogen receptor (ER) and this acts to turn on, or turn off, other genes which sculpt the neural architecture required for adult function," said the study's main author, Emilie Rissman, PhD, a professor of biochemistry and molecular genetics at U.Va. and a specialist in the genetics of mammalian behavior. "We'd like to find out what the genes are, where precisely they reside in the brain, when in development this happens, and what the cellular targets are of these genes," Rissman said. Interestingly, male fetuses are exposed to estrogen in their normal development and females are not because ovaries don't fully develop until puberty.

This newly described role for ER could be important in research on behavioral differences between men and women, Rissman said, such as in the areas of aggression, nurturing, and cognition. The discovery could also help scientists find out why some diseases target men and women differently, Rissman said, including depression, Al
'"/>

Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
11-Mar-2005


Page: 1 2

Related biology news :

1. Learning to evolve: With a little help from my ancestors
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Local interventions have little effect on metapopulation stability
4. Marathon mice elucidate little-known muscle type
5. A little of what you fancy does you no good
6. Universal design tackles little things with big impact
7. Coffee, black, decaf and a little llama on the side
8. Eating less fat may lower breast-cancer risk, have little impact on colon-cancer, heart-disease risk
9. Earliest European farmers left little genetic mark on modern Europe, Science study finds
10. Major losses projected for earthquake on little-known fault under Los Angeles
11. Marshes tell story of medieval drought, little ice age, and European settlers near NYC

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 09, 2018 , ... ... life science and biotechnology companies, announced today that it will host a ... their investment philosophies, explain their fund and deal structures, and describe how ...
(Date:10/11/2018)... ... 11, 2018 , ... Better lives through a healthy society ... in Manufacturing Biopharmaceuticals (NIIMBL). The Institute, a public-private partnership launched in March 2017, ... development in the United States. Biopharmaceuticals are important because they treat and prevent ...
(Date:10/5/2018)... (PRWEB) , ... October 04, 2018 , ... High dose ... some of the tests such as cardiac troponin has serious clinical complications. There is ... the exact prevalence is still unknown. , High dose of biotin supplement use ...
Breaking Biology News(10 mins):
(Date:10/5/2018)... Calif. (PRWEB) , ... October 04, 2018 , ... ... disease diagnostics with genomics, along with Duke University, announced today at IDWeek™ 2018 ... blood test that detects pathogen DNA in plasma, accurately identified causative pathogens in ...
(Date:10/5/2018)... ... 2018 , ... Earthres Group, Inc., a multi-disciplinary engineering firm, ... identity and better reflects its current breadth of markets and services. Marketing now ... related support services to clients in seven market sectors, and currently operates in ...
(Date:10/2/2018)... , ... October 02, 2018 ... ... advanced software solutions for biopharmaceutical R&D, today announced a new out-of-the-box integration ... from Sartorius, a leading international pharmaceutical and laboratory equipment supplier. This enables ...
(Date:10/2/2018)... ... October 02, 2018 , ... Contamination ... the reliability and reproducibility of experimental data. Each lab must consider whether ethanol ... webinar, which is sponsored by Eppendorf , attendees will learn how to ...
Breaking Biology Technology:
Cached News: