What causes Alzheimer's? Researchers tie beta-amyloids to brain dysfunction

WASHINGTON, D.C.Researchers tied the accumulation of the toxic brain protein beta-amyloid to Alzheimer's disease, according to a study reported at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals.

"Our findings show that beta-amyloid is associated with brain dysfunctioneven in apparently normal elderly individualsproviding further evidence that it is likely related to the fundamental cause of Alzheimer's disease," said Christopher Rowe, director of the nuclear medicine department and Centre for PET at Austin Hospital in Melbourne, Victoria, Australia. Additionally, in using agent PIB (Pittsburgh Compound B) and positron emission tomography (PET), researchers "demonstrated that PIB PET is able to detect the early pathological changes of Alzheimer's disease long before the development of dementia," he indicated. "Trials of anti-amyloid drugs are underway. If these prove successful, amyloid imaging will have a vital role in identifying those in need of treatment to prevent the development of Alzheimer's dementia," added Rowe.

Alzheimer's diseasea progressive, irreversible brain disorderis a formidable opponent with no known cause or cure. More than 4.5 million Americans are thought to have this disease that attacks and slowly steals the minds of its victims. Alzheimer's impacts every nation where life expectancy has increased; estimates indicate that there are now 18 million people worldwide with the disease.

One of the hallmarks of the always-fatal disease is the accumulation of protein amyloid plaques between nerve cells in the brain. Beta-amyloid is a protein fragment that normally is broken down and eliminated in a healthy brain. With Alzheimer's, these fragments form hard, insoluble plaques. Prior to the development of PIB and use of PET imaging, the presence of plaque could be confirmed only during autopsy. "Buildup of beta-amyloid in the brain is thought to be t

Contact: Maryann Verrillo
Society of Nuclear Medicine

Page: 1 2 3

Related biology news :

1. Pollution causes 40 percent of deaths worldwide, study finds
2. Pregnant mothers join search for causes of autism
3. Marijuana component opens the door for virus that causes Kaposis sarcoma
4. Faulty cell membrane repair causes heart disease
5. Study suggests other causes for childhood brain aneurysms
6. Understanding why C. difficile causes disease -- its hungry
7. U of MN will lead national research study on causes of bone cancer in children
8. Book explores history, causes of allergy and asthma epidemic
9. Study of damaged gene gives insight into causes of mental illness
10. New clues for treatment of disease that causes accelerated aging
11. Class of PCBs causes developmental abnormalities in rat pups

Post Your Comments:

(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, a fast-growing ... that Eric Chen and Jessica Wong have joined the company’s leadership team as ... , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, an innovative ...
(Date:7/31/2020)... Md. (PRWEB) , ... July 30, 2020 , ... ... Innovation Research (SBIR) Phase II contract awarded by the Joint Science & Technology ... of this project is to develop, optimize, and scale-up a highly efficient mammalian ...
(Date:7/18/2020)... ... 17, 2020 , ... Commercial launch readiness is a critical stage in a ... cure or vaccine, the global economic downturn will only increase price pressures overall for ... and capturing full value from every product launch is critical. However, history shows that ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... highly reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, ... single controller that can drive one or two switches in a push-pull configuration; ...
(Date:7/31/2020)... ... July 30, 2020 , ... Alucio™, ... announced the release of its signature product called Beacon - a content ... other field medical professionals. , Beacon helps MSLs streamline communication and ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
(Date:7/7/2020)... ... , ... R3 International is now offering stem cell therapy for Alzheimers dementia ... on the patient's condition, treatment may be offered IV, intrathecal or with a combination. ... Alzheimers dementia, and the incidence continues to increase as individuals live longer. There is ...
Breaking Biology Technology:
Cached News: