HOME >> BIOLOGY >> NEWS
When it comes to cell entry, being average has its advantages

PROVIDENCE, R.I. -- When it comes to gaining entry into cells, size matters. A team from Brown University and the Max Planck Institute for Metals Research has created a model that explains how viruses and other bioparticles slip inside cells without a special protein coating called clathrin.

The secret, it seems, is to be average. Mid-sized nanomaterials about 27 to 30 nanometers in diameter, or about 1,000 times thinner than a human hair are optimal for cellular entry. In a research article to be posted this week in the online edition of the Proceedings of the National Academy of Sciences, the researchers note that this information is significant for developing gene and drug delivery tools as well as assessing the safety of nanotubes infinitesimal bits of carbon and other materials used in everything from cameras to clothing.

"If you know how viruses get into cells, you know how to better design drugs to keep them out," said L.B. Freund, professor of engineering at Brown. "Or if you do want molecules to get in those in medication, say knowing an optimal particle size for entry is also helpful.

"With nanotubes, we may be able to manufacture ones of a certain size to minimize chances that they'll enter and perhaps harm cells."

The type of cell entry the team studied is called receptor-mediated endocytosis.

Here's how it happens: A virus or other particle arrives at the cell membrane. Protein receptors on the membrane act like hooks, grabbing onto hooks, or ligands, on the particle, much like two pieces of Velcro. As more and more chemical hooks are recruited for the task, the membrane wraps around the particle until it is completely engulfed. This is how herpes and influenza viruses get inside cells.

The process is believed usually to involve clathrin, a protein that coats the invader to aid in the Velcro-like fastening. Yet scientists have shown that flu viruses can invade cells even without a clathrin coat. Along
'"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
22-Jun-2005


Page: 1 2

Related biology news :

1. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
2. Skin rash actually signifies better outcomes for pancreatic and lung cancer patients
3. Arctic spring comes weeks earlier than a decade ago
4. New algorithms classify outcomes of nonsmall cell lung cancer patients
5. When the villain becomes your friend: The strange tale of muscle lactate
6. Eavesdropping comes naturally to young song sparrows
7. Latent memory of cells comes to life
8. Nemo comes home with a tag
9. Breathing easy: When it comes to oxygen, a bugs life is full of it
10. Improving outcomes in premature births
11. PNNL becomes DOE flagship for incentive-based waste management practices

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: