HOME >> BIOLOGY >> NEWS
White blood cell 'waste disposal' system plays critical regulatory role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells.

Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes.

Although the specific mechanisms that regulate the proper ratios of neutrophil production and destruction are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered molecule called IL-23 that is produced by phagocytes has been shown to stimulate IL-17 production. Dr. Klaus Ley and colleagues from the University of Virginia investigated whether ingestion of apoptotic neutrophils influenced IL-23 production by phagocytes.

The researchers observed that the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 an
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
22-Mar-2005


Page: 1 2

Related biology news :

1. White blood cells are picky about sugar
2. UTSA neurobiologist awarded $225,000 from Whitehall Foundation
3. Whiteflies and plant viruses can help each other to speed up biological invasion
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Former White House science advisor warns that nanotechnologys potential threatened
7. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
8. White blood cells from cancer-resistant mice cure cancers in ordinary mice
9. White-coat effect is virtually eliminated using a non-drug hypertension
10. Great White shark evolution debate involves WSU Lake Campus geology professor
11. High blood pressure, low energy -- a recipe for heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... ... to clients throughout the biopharma and life sciences industries, continue to be in ... seeing. Tunnell’s Kip Wolf will be speaking on “The State of Information Governance ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased ... test was determined to be appropriate as a screening test at dairies and farms ... Charm EZ system, and the Charm EZ Lite system. These systems are a combination ...
(Date:6/20/2017)... ... June 20, 2017 , ... HorizonScan ... adulterants which pose the most likely threat to their products at the annual ... , IFT's annual food expo attracts over 20,000 attendees representing food science ...
(Date:6/20/2017)... ... ... Do More with OHAUS , With the launch of the new laboratory equipment ... to extending its expertise across the entire laboratory to a range of life science ... for its customers to 'Do More' in the lab. , Efficiency and Safety ...
Breaking Biology Technology:
Cached News: