HOME >> BIOLOGY >> NEWS
White blood cell 'waste disposal' system plays critical regulatory role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells.

Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes.

Although the specific mechanisms that regulate the proper ratios of neutrophil production and destruction are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered molecule called IL-23 that is produced by phagocytes has been shown to stimulate IL-17 production. Dr. Klaus Ley and colleagues from the University of Virginia investigated whether ingestion of apoptotic neutrophils influenced IL-23 production by phagocytes.

The researchers observed that the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 an
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
22-Mar-2005


Page: 1 2

Related biology news :

1. White blood cells are picky about sugar
2. UTSA neurobiologist awarded $225,000 from Whitehall Foundation
3. Whiteflies and plant viruses can help each other to speed up biological invasion
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Former White House science advisor warns that nanotechnologys potential threatened
7. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
8. White blood cells from cancer-resistant mice cure cancers in ordinary mice
9. White-coat effect is virtually eliminated using a non-drug hypertension
10. Great White shark evolution debate involves WSU Lake Campus geology professor
11. High blood pressure, low energy -- a recipe for heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... ... ... Throughout the month of October, consumers will see thousands of their favorite ... industry expert David Carter is available to explain why so many leading brands and ... demand for non-GMO foods and beverages is gathering momentum, as consumers want to know ...
(Date:9/25/2017)... ... September 25, 2017 , ... Comprehend, ... presentations and demonstrations at SCDM 2017, held September 24-27, 2017 in Orlando. ... and CRO partners for more automated capabilities across evolving data, Comprehend delivers ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... venous leg ulcers is now being assessed in clinical trials in the United ... please talk to your nurse or physician or find your nearest participating clinic ...
(Date:9/21/2017)... ... September 21, 2017 , ... Executives and subject ... most progressive pharma and biotech organizations to do more clinical trials will share ... events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s first unified ...
Breaking Biology Technology:
Cached News: