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White blood cell 'waste disposal' system plays critical regulatory role

d IL-17 dropped considerably.

The researchers conclude that a major mechanism for regulation of neutrophil production involves secretion of IL-23 that is regulated by phagocytosis of apoptotic neutrophils. "The discovery of neutrophil-regulating cells suggests new ways to manipulate the inflammatory system and neutrophil production with possible relevance to the treatment of inflammatory diseases and the mitigation of chemotherapy-induced neutropenia," says Dr. Ley.


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Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
22-Mar-2005


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