HOME >> BIOLOGY >> NEWS
White blood cells in lung produce histamine seen in allergies

In a surprise finding, scientists have discovered that histamine, the inflammatory compound released during allergic reactions that causes runny nose, watery eyes, and wheezing, can be produced in large amounts in the lung by neutrophils, the white blood cells that are the major component of pus.

Pus, a fluid found in infected tissue, is produced as a result of inflammation.

The study in mice is the first to show that lung neutrophils can produce histamine in significant quantities, according to principal investigator George Caughey, MD, chief of pulmonary/critical care medicine at the San Francisco VA Medical Center.

"Previously it was thought that the primary sources of lung histamine, in health as well as disease, was mast cells, which are classically associated with allergy," notes Caughey, who is also a professor of medicine at the University of California, San Francisco.

Caughey says the result could mean that histamine acts as a link between airway infections and asthma and bronchitis, which are associated with allergy. "In both, we observe inflammation swelling, blood vessel leak, and muscle contraction that narrows the airway."

The study appears in the January 2007 issue of the Journal of Experimental Medicine.

Caughey was investigating the well-known fact that upper respiratory infections often trigger acute asthma attacks. "We hypothesized that an infection in the airway would release histamine from mast cells, and that would be one of the reasons," he explains.

To test the hypothesis, Caughey and his team exposed two different populations of mice to mycoplasma, a common respiratory infection in rodents and humans. One population had a genetic abnormality that causes a total lack of mast cells; the other population was made up of normal, wild-type mice. Both populations of infected mice developed pneumonia.

"We thought the mice without mast cells would do better than the wild-t
'"/>

Contact: Steve Tokar
steve.tokar@ncire.org
415-221-4810 x5202
University of California - San Francisco
12-Jan-2007


Page: 1 2 3

Related biology news :

1. White blood cells are picky about sugar
2. UTSA neurobiologist awarded $225,000 from Whitehall Foundation
3. Whiteflies and plant viruses can help each other to speed up biological invasion
4. Whitefly spreads emerging plant viruses
5. Former White House science advisor warns that nanotechnologys potential threatened
6. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
7. White blood cells from cancer-resistant mice cure cancers in ordinary mice
8. White-coat effect is virtually eliminated using a non-drug hypertension
9. Great White shark evolution debate involves WSU Lake Campus geology professor
10. White blood cell waste disposal system plays critical regulatory role
11. High blood pressure, low energy -- a recipe for heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... WASHINGTON , July 20, 2017 Delta (NYSE: ... to board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics ... Delta,s ... Delta Sky Club is now integrated into the boarding process to ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... Precision Periodontics ... offering LANAP® and LAPIP™ laser treatments. Drs. Hoge and Zalewsky are members of ... minimally invasive and less painful option that produces real results. , "Like many ...
(Date:9/21/2017)... Colmar (France) , ... (PRWEB) September 21, 2017 ... ... is an international scientific and technical congress to review the latest knowledge on ... panel of prestigious international speakers will discuss the impact of Biostimulants on Plant ...
(Date:9/21/2017)... CALIF. (PRWEB) , ... September 21, 2017 , ... Lajollacooks4u ... this month. The organization, a worldwide society of professional women with high achievement ... to hold its annual dinner. , Twelve members began with an olive ...
(Date:9/20/2017)... Bell, PA and College Station, TX (PRWEB) , ... ... ... IPS-Integrated Project Services, LLC (IPS), a leading global provider of ... Manufacturing, Inc. the leading provider of prefabricated cleanrooms, today announced the unveiling ...
Breaking Biology Technology:
Cached News: