HOME >> BIOLOGY >> NEWS
White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

WINSTON-SALEM, N.C. The discoverers of the unique mouse line that is resistant to cancer have begun to pin down how the process works and found that white blood cells in these mice overwhelm normal defenses of cancer cells.

In a report in Cancer Immunity, a journal of the Academy of Cancer Immunology, posted on line today, Zheng Cui, M.D., Ph.D., and Mark C. Willingham, M.D., of Wake Forest University School of Medicine and colleagues said that several types of white blood cells in the mice attack cancer cells by sensing, finding and surrounding them, forming a "rosette," and then killing them.

"Apparently, the mutation in the cancer-resistant mice renders the white blood cells capable of sensing unique diffusible and surface signals from cancer cells and responding to those signals by migration and physical contact," they said.

The researchers said that in ordinary mice, the white blood cells are suppressed by self-defensive signals coming from the cancer cells and don't attack the cancer. But the mutated gene or genes in the cancer-resistant mouse changes the white blood cells so they interpret those same signals from the cancer cells as an invitation to attack.

"Identifying the mutated gene (or genes) will likely explain this unique resistance to cancer through immunity," said Cui, associate professor of pathology.

Earlier this year, the same team reported in the Proceedings of the National Academy of Sciences that white blood cells taken from these cancer-resistant mice cured advanced cancers in ordinary mice and also protected those normal mice from what should have been lethal doses of highly aggressive new cancers.

But while pursuing the ability of these white blood cells to cure cancer in ordinary mice, and beginning to explore whether the same process could work in humans, the researchers have also continued to investigate how the original mutation works, a mutation that protects the cancer-resistant mice from a wide va
'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
31-Oct-2006


Page: 1 2

Related biology news :

1. White blood cells are picky about sugar
2. UTSA neurobiologist awarded $225,000 from Whitehall Foundation
3. Whiteflies and plant viruses can help each other to speed up biological invasion
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Former White House science advisor warns that nanotechnologys potential threatened
7. White blood cells from cancer-resistant mice cure cancers in ordinary mice
8. White-coat effect is virtually eliminated using a non-drug hypertension
9. Great White shark evolution debate involves WSU Lake Campus geology professor
10. White blood cell waste disposal system plays critical regulatory role
11. High blood pressure, low energy -- a recipe for heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Personal eye wash is a basic first aid supply for any work environment, ... eye do you rinse first if a dangerous substance enters both eyes? It’s one less ... with its unique dual eye piece. , “Whether its dirt and debris, or an acid ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
Breaking Biology Technology:
Cached News: