Why do aneurysms form? New studies suggest leading role for white b...( had significantly smaller aneurysms aft...)

had significantly smaller aneurysms after elastase exposure, and only 38 percent of them developed aneurysms compared with 67 percent of the normal rats. Days after the injury, far fewer neutrophils and macrophage whit blood cells were present in the aorta walls of the rats that lacked L-selectin.

"Much further research is needed, but it's possible that a treatment based on L-selectin could be developed to prevent AAA development in high-risk patients," says Upchurch. "In addition to better screening and adequate monitoring of known AAAs, this kind of treatment is badly needed."

Upchurch and his colleagues performed the research in the Conrad Jobst Vascular Research Laboratories, part of the Section of Vascular Surgery in the U-M Medical School. They were funded by the National Institutes of Health, the Lifeline Foundation and the Jobst Vascular Research Fund. Upchurch is an associate professor of vascular surgery and the Leland Ira Doan Research Professor of Vascular Surgery at the U-M Medical School.

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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
13-Jul-2005

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