HOME >> BIOLOGY >> NEWS
World-first stem cell research could aid male infertility

Scientists have shown for the first time that sperm grown from embryonic stem cells can be used to produce offspring.

The experiment was carried out using mice and produced seven babies, six of which lived to adulthood.

The breakthrough, reported today, Monday July 10, in the academic journal Developmental Cell, helps scientists to understand more about how animals produce sperm. This knowledge has potential applications in the treatment of male infertility.

Karim Nayernia, who has just taken up a post as Professor of Stem Cell Biology at Newcastle University, led the research while in his previous position at Georg-August University in Gttingen, Germany, with Prof. Dr Wolfgang Engel and colleagues from Germany and the UK, including Dr. David Elliott from Newcastle University's Institute of Human Genetics.

Stem cells have the potential to develop into any tissue type in the body and could therefore be used to develop a wide range of medical therapies.

Prof Nayernia, of the Newcastle-Durham-NHS Institute for Stem Cell Biology and Regenerative Medicine*, and his team describe in their paper how they developed a new strategy for generating mature sperm cells in the laboratory using embryonic stem cells from mice. They then went on to test whether this sperm would function in real life.

The team isolated stem cells from a blastocyst, an early-stage embryo that is a cluster of cells only a few days old.

These cells were grown in the laboratory and screened using a special sorting machine. Some had grown into a type of stem cell known as 'spermatogonial stem cells', or early-stage sperm cells.

The spermatogonial cells were singled out, then genetically marked and grown in the laboratory. Some of them grew into cells resembling sperm, known as gametes, which were themselves singled out and highlighted using a genetic marker.

The sperm that had been derived from the embryon
'"/>

Contact: Claire Jordan
press.office@ncl.ac.uk
191-222-7850
University of Newcastle upon Tyne
10-Jul-2006


Page: 1 2 3

Related biology news :

1. World-first technology enables study of ancient bacteria
2. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
3. Saudi Arabias KAUST names WHOI first research partner
4. Multinational research: protecting ecology means understanding people, too
5. Newly created cancer stem cells could aid breast cancer research
6. Carnegie Mellons Peter Adams receives EPA research grant
7. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
8. Innovative tagging technique may help researchers better protect fish stocks
9. Penn researchers discover how key protein stops inflammation
10. UCF research links proteins, stem cells and potential Alzheimers treatment
11. ASU researchers partner with UOP to make biofuel for military jets a reality

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... , ... ActX has launched a medical genetic interpretation ... can get access to professionally reviewed genetic screening similar to what a physician ... + Ancestry customers., With the ActX + 23andMe service, both 23andMe customers and ...
(Date:6/24/2019)... ... , ... According to the World Health Organization , over a million ... gonorrhea, trichomoniasis (or "trich") and syphilis. And that’s not counting HIV. , In ... for the largest number of HIV diagnoses (9,807), followed by Hispanic/Latino men (7,436) and ...
(Date:6/20/2019)... ... June 19, 2019 , ... ... Infectious Diseases Society of America Foundation, and the possibly millions of dollars of ... infectious agents in AD, are a “welcome affirmation” of the need to investigate ...
Breaking Biology News(10 mins):
(Date:6/26/2019)... ... ... Alice Branton today released research results from preclinical trials on the beneficial ... prove to be beneficial for treating Hypomagnesemia. , The preclinical trial shows:, ... , Over 142% increase in particle size , Over 3% ...
(Date:6/18/2019)... YORK and SOMERSET, N.J. (PRWEB) , ... June ... ... Catalent Biologics, today announced that they have entered into an agreement for production ... product candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) ...
(Date:6/18/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell ... of a person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical ... IND is the first of several planned clinical trials which will enable qualified PSC-enrolled ...
(Date:6/12/2019)... (PRWEB) , ... June 12, 2019 , ... ... built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food ... Zillion has been signed. The agreement will grant exclusive rights for Zillion to ...
Breaking Biology Technology:
Cached News: