HOME >> BIOLOGY >> NEWS
World's largest population study on BRCA1/2

The largest population study ever done into the risk of cancer in families that fulfil the criteria for BRCA1 and BRCA2 mutation testing has confirmed that breast and ovarian cancers are the major concerns for geneticists and doctors counselling families. It has also verified that families eligible for BRCA1/2 mutation testing are at increased risk of pancreatic, prostate and stomach cancers.

One important conclusion of the study was that, in families with at least one woman with breast cancer and another woman with ovarian cancer, most ovarian cancers are not attributable to BRCA1/2 mutations. Other, as yet unknown, non-BRCA1/2 related factors are likely to increase the risk of ovarian cancer in those families.

The study, published Monday 15 November in Annals of Oncology[1], utilised the 2002 update of the Swedish Family-Cancer Database, which contains everyone born in Sweden after 1931 with their biological parents a total of 10.2 million people. Nearly 948,000 families with at least three generations were classified according to the clinical criteria proposed by the German Consortium for Hereditary Breast and Ovarian Cancer for testing of BRCA1/2 mutations.

The researchers Dr Justo Lorenzo Bermejo and Professor Kari Hemminki compared the cancer incidence in families eligible for BRCA1/2 mutation testing with the incidence in the general Swedish population. They used literature data to estimate the proportion of familial cancers unrelated to BRCA1/2 mutations.

Dr. Lorenzo Bermejo, postdoctoral research fellow at the Department of Molecular Genetic Epidemiology at the German Cancer Research Center in Heidelberg, said: "The close to 100% histological verification of cancers in the database, its size and its coverage offered us a unique possibility to perform this analysis. Our objective was to assess the risk of cancer in high-risk breast/ovarian cancer families at a population level. Data about the risk in BRCA1/2 carriers ar
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-153-677-2181
European Society for Medical Oncology
14-Nov-2004


Page: 1 2 3

Related biology news :

1. Worlds first X-ray free electron laser is on course to completion
2. Worlds leading scientists announce creation of Encyclopedia of Life
3. Worlds top engineers in San Antonio for system of systems conference
4. Worlds oldest rocks show how Earth may have dodged frozen fate of Mars
5. Worlds largest flower evolved from family of much tinier blooms
6. Worlds coral reef left vulnerable by paper parks
7. Worlds coral reefs left vulnerable by paper parks
8. Worlds tiniest test tubes get teensiest corks
9. Worlds largest study on changes to Earths ecosystems released on May 19
10. Worlds largest rainforest drying experiment completes first phase
11. Worlds largest scientific society backs green chemistry bill

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: World largest population study BRCA1

(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... Most cancer deaths occur because of metastasis, yet ... has been slow. , "It,s been particularly challenging ... Taran Gujral, research fellow in systems biology at ... aren,t detected until after they,ve already metastasized." , ... culprit that should help researchers better understand how ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2
(Date:11/26/2014)... The North America Thermal Protective ... for detailed analysis of the growth trends and ... $616.3 million by 2018, growing at a CAGR ... through the TOC of the North America Thermal ... of the in-depth analysis and industry segmentation supported ...
(Date:11/26/2014)... 26, 2014 On January, 14, 2015, ... and Washington D.C. science community to the UMBC campus ... sponsored by the Protein Society, will take place from ... Room 312. Through discussion, presentations and workshops, the ... of proteins, their role in the industry and the ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) provider ... provider of clinical research and data management services to ... its CRO Partnership Program, Clinovo expands ClinCapture , ... , “We have found Clinovo’s ClinCapture to exceed our ... is both user friendly and easy to deploy. The ...
(Date:11/26/2014)... 2014 SoundConnect , an award ... to announce that Darren Suders has joined the team ... will drive the partner program through innovative ... , Darren brings more than 10-years of channel ... in channel operations, from policy development, to partner education ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2
Cached News: