HOME >> BIOLOGY >> NEWS
World's largest population study on BRCA1/2

The largest population study ever done into the risk of cancer in families that fulfil the criteria for BRCA1 and BRCA2 mutation testing has confirmed that breast and ovarian cancers are the major concerns for geneticists and doctors counselling families. It has also verified that families eligible for BRCA1/2 mutation testing are at increased risk of pancreatic, prostate and stomach cancers.

One important conclusion of the study was that, in families with at least one woman with breast cancer and another woman with ovarian cancer, most ovarian cancers are not attributable to BRCA1/2 mutations. Other, as yet unknown, non-BRCA1/2 related factors are likely to increase the risk of ovarian cancer in those families.

The study, published Monday 15 November in Annals of Oncology[1], utilised the 2002 update of the Swedish Family-Cancer Database, which contains everyone born in Sweden after 1931 with their biological parents a total of 10.2 million people. Nearly 948,000 families with at least three generations were classified according to the clinical criteria proposed by the German Consortium for Hereditary Breast and Ovarian Cancer for testing of BRCA1/2 mutations.

The researchers Dr Justo Lorenzo Bermejo and Professor Kari Hemminki compared the cancer incidence in families eligible for BRCA1/2 mutation testing with the incidence in the general Swedish population. They used literature data to estimate the proportion of familial cancers unrelated to BRCA1/2 mutations.

Dr. Lorenzo Bermejo, postdoctoral research fellow at the Department of Molecular Genetic Epidemiology at the German Cancer Research Center in Heidelberg, said: "The close to 100% histological verification of cancers in the database, its size and its coverage offered us a unique possibility to perform this analysis. Our objective was to assess the risk of cancer in high-risk breast/ovarian cancer families at a population level. Data about the risk in BRCA1/2 carriers ar
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-153-677-2181
European Society for Medical Oncology
14-Nov-2004


Page: 1 2 3

Related biology news :

1. Worlds first X-ray free electron laser is on course to completion
2. Worlds leading scientists announce creation of Encyclopedia of Life
3. Worlds top engineers in San Antonio for system of systems conference
4. Worlds oldest rocks show how Earth may have dodged frozen fate of Mars
5. Worlds largest flower evolved from family of much tinier blooms
6. Worlds coral reef left vulnerable by paper parks
7. Worlds coral reefs left vulnerable by paper parks
8. Worlds tiniest test tubes get teensiest corks
9. Worlds largest study on changes to Earths ecosystems released on May 19
10. Worlds largest rainforest drying experiment completes first phase
11. Worlds largest scientific society backs green chemistry bill

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: World largest population study BRCA1

(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: ... at the following conferences, and invited investors to participate via ... Boston, MA Tuesday, March 3, 2015 at ... Conference, Orlando, FL Wednesday, March 4, ... Webcasts To access the live webcasts for these events, please ...
(Date:2/12/2015)... , Feb. 12, 2015   MedNet ... specializing in clinical study management systems, has recently ... , further distinguishing iMedNet ... Research Organizations (CROs) and healthcare consultants.  Building on ... prospective customer referrals and numerous co-marketing opportunities), MedNet,s ...
(Date:2/11/2015)... , February 11, 2015 ... report "Access Control Market by Product (Cards and Readers, ... Military and Defense, Government, Industrial, Healthcare, Education) and By ... by MarketsandMarkets, the Access Control Market is ... growing at a CAGR of 10.6% between ...
Breaking Biology News(10 mins):Cepheid to Webcast Upcoming Financial Presentations 2MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
(Date:3/3/2015)... March 3, 2015  Rosa & Co. LLC, a ... and simulation research, today announced it has two posters ... for Clinical Pharmacology and Therapeutics meeting in ... Logo - http://photos.prnewswire.com/prnh/20150302/179058LOGO   ... a poster describing a quantitative systems pharmacology approach for ...
(Date:3/3/2015)... 03, 2015 Genedata, a leading ... and life science research, today announced that Pfizer ... platform for use at Pfizer biopharma research and ... is supporting Pfizer’s global deployment and roll out ... for Therapeutic Innovation (CTI), and Pharmaceutical Sciences groups. ...
(Date:3/3/2015)... 03, 2015 Research and Markets ... Jain PharmaBiotech,s new report "Gene Therapy - ... , Gene therapy technologies are ... and cell therapy with genetically modified vectors. Gene ... and various routes of administration as well as ...
(Date:3/3/2015)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a developer of ... on protecting the microbiome, announced today that Jeffrey Riley ... 27th Annual ROTH Conference being held on March 8-11, 2015 ... Dana Point, CA. Mr. Riley is ... p.m. (Pacific Time). A live webcast of Synthetic ...
Breaking Biology Technology:Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 2Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 3Genedata Biologics Licensed by Pfizer Inc. 2Genedata Biologics Licensed by Pfizer Inc. 3Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 2Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 3Synthetic Biologics to Present at the 27th Annual ROTH Conference 2
Cached News: